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• W2547989391 abstract "White spot lesions (WSLs), due to enamel demineralization, occur frequently in orthodontic treatment. We recently developed a novel rechargeable dental composite containing nanoparticles of amorphous calcium phosphate (NACP) with long-term calcium (Ca) and phosphate (P) ion release and caries-inhibiting capability. The objectives of this study were to develop the first NACP-rechargeable orthodontic cement and investigate the effects of recharge duration and frequency on the efficacy of ion re-release. The rechargeable cement consisted of pyromellitic glycerol dimethacrylate (PMGDM) and ethoxylated bisphenol A dimethacrylate (EBPADMA). NACP was mixed into the resin at 40% by mass. Specimens were tested for orthodontic bracket shear bond strength (SBS) to enamel, Ca and P ion initial release, recharge and re-release. The new orthodontic cement exhibited an SBS similar to commercial orthodontic cement without CaP release (P>0.1). Specimens after one recharge treatment (e.g., 1 min immersion in recharge solution repeating three times in one day, referred to as 1 min 3 times) exhibited a substantial and continuous re-release of Ca and P ions for 14 days without further recharge. The ion re-release did not decrease with increasing the number of recharge/re-release cycles (P>0.1). The ion re-release concentrations at 14 days versus various recharge treatments were as follows: 1 min 3 times>3 min 2 times>1 min 2 times>6 min 1 time>3 min 1 time>1 min 1 time. In conclusion, although previous studies have shown that NACP nanocomposite remineralized tooth lesions and inhibited caries, the present study developed the first orthodontic cement with Ca and P ion recharge and long-term release capability. This NACP-rechargeable orthodontic cement is a promising therapy to inhibit enamel demineralization and WSLs around orthodontic brackets." @default.
• W2547989391 created "2016-11-11" @default.
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• W2547989391 date "2016-11-04" @default.
• W2547989391 modified "2023-10-12" @default.
• W2547989391 title "Novel rechargeable calcium phosphate nanoparticle-containing orthodontic cement" @default.
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• W2547989391 doi "https://doi.org/10.1038/ijos.2016.40" @default.
• W2547989391 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5379158" @default.
• W2547989391 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27811847" @default.
• W2547989391 hasPublicationYear "2016" @default.
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