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- W2548015249 abstract "Hemophagocytic lymphohistiocytosis (HLH) is a hyperinflammatory syndrome characterized by excessive activation of macrophages and T cells resulting from defective cytotoxicity. It is potentially life threatening due to the large amounts of cytokines released by the activated macrophages and lymphocytes secondary to a hyperinflammatory response. It has a high fatality in children with an incidence of approximately 1.2 cases/million per year. The literature was extensively searched in PubMed, MEDLINE and Google scholar. A variable and nonspecific symptomatology can delay the diagnosis and hence requires a high index of suspicion in both primary and secondary HLH." @default.
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- W2548015249 date "2017-05-01" @default.
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- W2548015249 title "Recent advances in diagnostic and therapeutic guidelines for primary and secondary hemophagocytic lymphohistiocytosis" @default.
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- W2548015249 doi "https://doi.org/10.1016/j.bcmd.2016.10.023" @default.
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