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• W2548044510 endingPage "1832" @default.
• W2548044510 startingPage "1832" @default.
• W2548044510 abstract "The interferon α (IFN-α) has been often used as a sensitizing agent for the treatment of various malignancies such as hepatocellular carcinoma, malignant melanoma, and renal cell cancer by promoting the apoptosis of thesetumor cell types. However, the effect of IFN-α on cervical cancer remains unknown. In this study, HeLa cells were used as a testing model for the treatment of IFN-α on cervical cancer. The results indicate that IFN-α markedly inhibits the proliferation and induces the apoptosis of HeLa cells. The activation of caspase 3, the up-regulation of both Bim and cleaved poly (ADP-ribose) polymerase (PARP) 1, the down-regulation of Bcl-xL, as well as the release of cytochrome c from mitochondria were significantly induced upon IFN-α treatment, indicating that the intrinsic apoptotic pathway could be activated by IFN-α treatment. In addition, caspase 4—which is involved in the endoplasmic reticulum (ER) stress-induced apoptosis—was activated in response to IFN-α treatment. Knocking down caspase 4 by small interfering RNA (siRNA) markedly reduced the IFN-α-mediated cell apoptosis. However, no significant changes in the expressions of caspases 8 and 10 were observed upon IFN-α treatment, indicating that the apoptosis caused by IFN-α might be independent of the extrinsic apoptotic pathway. These findings suggest that IFN-α may possess anti-cervical cancer capacity by activating cell apoptosis via the intrinsic mitochondrial pathway and caspase-4-related ER stress-induced pathway." @default.
• W2548044510 created "2016-11-11" @default.
• W2548044510 creator A5033245675 @default.
• W2548044510 creator A5034955183 @default.
• W2548044510 creator A5063481044 @default.
• W2548044510 date "2016-11-02" @default.
• W2548044510 modified "2023-10-03" @default.
• W2548044510 title "Interferon α Induces the Apoptosis of Cervical Cancer HeLa Cells by Activating both the Intrinsic Mitochondrial Pathway and Endoplasmic Reticulum Stress-Induced Pathway" @default.
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• W2548044510 doi "https://doi.org/10.3390/ijms17111832" @default.
• W2548044510 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5133833" @default.
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• W2548044510 hasPublicationYear "2016" @default.
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