FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2548141917> ?p ?o ?g. }

• W2548141917 abstract "Experimental evolution studies can be used to explore genomic response to artificial and natural selection. In such studies, loci that display larger allele frequency change than expected by genetic drift alone are assumed to be directly or indirectly associated with traits under selection. However, such studies report surprisingly many loci under selection, suggesting that current tests for allele frequency change may be subject to P-value inflation and hence be anticonservative. One factor known from genomewide association (GWA) studies to cause P-value inflation is population stratification, such as relatedness among individuals. Here, we suggest that by treating presence of an individual in a population after selection as a binary response variable, existing GWA methods can be used to account for relatedness when estimating allele frequency change. We show that accounting for relatedness like this effectively reduces false-positives in tests for allele frequency change in simulated data with varying levels of population structure. However, once relatedness has been accounted for, the power to detect causal loci under selection is low. Finally, we demonstrate the presence of P-value inflation in allele frequency change in empirical data spanning multiple generations from an artificial selection experiment on tarsus length in two free-living populations of house sparrow and correct for this using genomic control. Our results indicate that since allele frequencies in large parts of the genome may change when selection acts on a heritable trait, such selection is likely to have considerable and immediate consequences for the eco-evolutionary dynamics of the affected populations." @default.
• W2548141917 created "2016-11-11" @default.
• W2548141917 creator A5013532876 @default.
• W2548141917 creator A5018418669 @default.
• W2548141917 creator A5024797598 @default.
• W2548141917 creator A5025578281 @default.
• W2548141917 creator A5037887679 @default.
• W2548141917 creator A5046782564 @default.
• W2548141917 creator A5057095562 @default.
• W2548141917 creator A5063273493 @default.
• W2548141917 creator A5079170551 @default.
• W2548141917 creator A5084436468 @default.
• W2548141917 creator A5085842865 @default.
• W2548141917 date "2016-11-25" @default.
• W2548141917 modified "2023-10-06" @default.
• W2548141917 title "Controlling for P -value inflation in allele frequency change in experimental evolution and artificial selection experiments" @default.
• W2548141917 cites W1598363823 @default.
• W2548141917 cites W1949596230 @default.
• W2548141917 cites W1966914636 @default.
• W2548141917 cites W1972313907 @default.
• W2548141917 cites W1979802415 @default.
• W2548141917 cites W1986265706 @default.
• W2548141917 cites W1990275569 @default.
• W2548141917 cites W1995493114 @default.
• W2548141917 cites W1996197386 @default.
• W2548141917 cites W1996570221 @default.
• W2548141917 cites W2008047653 @default.
• W2548141917 cites W2009588715 @default.
• W2548141917 cites W2013223495 @default.
• W2548141917 cites W2016005141 @default.
• W2548141917 cites W2021773250 @default.
• W2548141917 cites W2024242286 @default.
• W2548141917 cites W2032457672 @default.
• W2548141917 cites W2036620956 @default.
• W2548141917 cites W2039608769 @default.
• W2548141917 cites W2041467022 @default.
• W2548141917 cites W2049802786 @default.
• W2548141917 cites W2062487333 @default.
• W2548141917 cites W2064301248 @default.
• W2548141917 cites W2065035179 @default.
• W2548141917 cites W2067424783 @default.
• W2548141917 cites W2072201802 @default.
• W2548141917 cites W2087043468 @default.
• W2548141917 cites W2097814038 @default.
• W2548141917 cites W2101549247 @default.
• W2548141917 cites W2104093114 @default.
• W2548141917 cites W2113258368 @default.
• W2548141917 cites W2113947265 @default.
• W2548141917 cites W2115692554 @default.
• W2548141917 cites W2115783150 @default.
• W2548141917 cites W2116668053 @default.
• W2548141917 cites W2118600492 @default.
• W2548141917 cites W2132611968 @default.
• W2548141917 cites W2135198859 @default.
• W2548141917 cites W2135229958 @default.
• W2548141917 cites W2139776178 @default.
• W2548141917 cites W2144065452 @default.
• W2548141917 cites W2149378411 @default.
• W2548141917 cites W2161245845 @default.
• W2548141917 cites W2162763466 @default.
• W2548141917 cites W2165017975 @default.
• W2548141917 cites W2171510674 @default.
• W2548141917 cites W2171679524 @default.
• W2548141917 cites W2176672531 @default.
• W2548141917 cites W2219486408 @default.
• W2548141917 doi "https://doi.org/10.1111/1755-0998.12631" @default.
• W2548141917 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27813315" @default.
• W2548141917 hasPublicationYear "2016" @default.
• W2548141917 type Work @default.
• W2548141917 sameAs 2548141917 @default.
• W2548141917 citedByCount "2" @default.
• W2548141917 countsByYear W25481419172021 @default.
• W2548141917 crossrefType "journal-article" @default.
• W2548141917 hasAuthorship W2548141917A5013532876 @default.
• W2548141917 hasAuthorship W2548141917A5018418669 @default.
• W2548141917 hasAuthorship W2548141917A5024797598 @default.
• W2548141917 hasAuthorship W2548141917A5025578281 @default.
• W2548141917 hasAuthorship W2548141917A5037887679 @default.
• W2548141917 hasAuthorship W2548141917A5046782564 @default.
• W2548141917 hasAuthorship W2548141917A5057095562 @default.
• W2548141917 hasAuthorship W2548141917A5063273493 @default.
• W2548141917 hasAuthorship W2548141917A5079170551 @default.
• W2548141917 hasAuthorship W2548141917A5084436468 @default.
• W2548141917 hasAuthorship W2548141917A5085842865 @default.
• W2548141917 hasBestOaLocation W25481419172 @default.
• W2548141917 hasConcept C104317684 @default.
• W2548141917 hasConcept C119857082 @default.
• W2548141917 hasConcept C144024400 @default.
• W2548141917 hasConcept C149923435 @default.
• W2548141917 hasConcept C180754005 @default.
• W2548141917 hasConcept C2908647359 @default.
• W2548141917 hasConcept C37463918 @default.
• W2548141917 hasConcept C41008148 @default.
• W2548141917 hasConcept C54355233 @default.
• W2548141917 hasConcept C68873052 @default.
• W2548141917 hasConcept C75268714 @default.
• W2548141917 hasConcept C78458016 @default.
• W2548141917 hasConcept C80990810 @default.
• W2548141917 hasConcept C81917197 @default.
• W2548141917 hasConcept C81941488 @default.

• next