Matches in SemOpenAlex for { <https://semopenalex.org/work/W2548164586> ?p ?o ?g. }
- W2548164586 endingPage "877" @default.
- W2548164586 startingPage "865" @default.
- W2548164586 abstract "Polyphenols are secondary metabolites of plants largely found in fruits, vegetables, cereals and beverages, and therefore represent important constituents of the human diet. Increasing studies have demonstrated the potential beneficial effects of polyphenols on human health. Extensive reviews have discussed the protective effects of polyphenols against a series of diseases such as cancer, cardiovascular diseases, diabetes, and neurodegenerative disorders. Limited studies have investigated the potential therapeutic effects of these natural compounds on neurodevelopmental disorders associated with intellectual disability, such as Down syndrome (DS), for which mitochondrial dysfunctions and oxidative stress are hallmarks and contribute to the deleterious symptoms and cognitive decline. This review, starting from the structure, source, bioavailability and pharmacokinetics of relevant polyphenols, highlights recent studies on the effect and potential molecular mechanism(s) of action of the phenolic compounds epigallocatechin-3-gallate, resveratrol and hydroxytyrosol in restoring mitochondrial energy deficit and in reversing phenotypical alteration in DS. The clinical implications of plant polyphenol dietary supplements as therapeutic tools in managing DS and other intellectual disability-related diseases, is also discussed." @default.
- W2548164586 created "2016-11-11" @default.
- W2548164586 creator A5002306582 @default.
- W2548164586 creator A5015562906 @default.
- W2548164586 creator A5018085259 @default.
- W2548164586 creator A5029824649 @default.
- W2548164586 creator A5034960645 @default.
- W2548164586 creator A5054475100 @default.
- W2548164586 date "2016-12-01" @default.
- W2548164586 modified "2023-10-17" @default.
- W2548164586 title "Plant polyphenols as natural drugs for the management of Down syndrome and related disorders" @default.
- W2548164586 cites W11920071 @default.
- W2548164586 cites W1262035166 @default.
- W2548164586 cites W1487878063 @default.
- W2548164586 cites W1511966243 @default.
- W2548164586 cites W1526705192 @default.
- W2548164586 cites W154151155 @default.
- W2548164586 cites W1564135916 @default.
- W2548164586 cites W1578492096 @default.
- W2548164586 cites W1598508662 @default.
- W2548164586 cites W1712017471 @default.
- W2548164586 cites W1743708126 @default.
- W2548164586 cites W1766288982 @default.
- W2548164586 cites W1827146465 @default.
- W2548164586 cites W1886477676 @default.
- W2548164586 cites W1926695909 @default.
- W2548164586 cites W1931422098 @default.
- W2548164586 cites W1968577394 @default.
- W2548164586 cites W1968643486 @default.
- W2548164586 cites W1969554270 @default.
- W2548164586 cites W1970681925 @default.
- W2548164586 cites W1972109005 @default.
- W2548164586 cites W1973303608 @default.
- W2548164586 cites W1974063776 @default.
- W2548164586 cites W1974428682 @default.
- W2548164586 cites W1976131488 @default.
- W2548164586 cites W1976799053 @default.
- W2548164586 cites W1981010581 @default.
- W2548164586 cites W1984485111 @default.
- W2548164586 cites W1984858667 @default.
- W2548164586 cites W1988824459 @default.
- W2548164586 cites W1990106417 @default.
- W2548164586 cites W1990567121 @default.
- W2548164586 cites W1991419045 @default.
- W2548164586 cites W1994799019 @default.
- W2548164586 cites W1997996740 @default.
- W2548164586 cites W1998619221 @default.
- W2548164586 cites W1999637509 @default.
- W2548164586 cites W1999864477 @default.
- W2548164586 cites W2000429523 @default.
- W2548164586 cites W2005128548 @default.
- W2548164586 cites W2005406899 @default.
- W2548164586 cites W2007207787 @default.
- W2548164586 cites W2010159317 @default.
- W2548164586 cites W2014583528 @default.
- W2548164586 cites W2015425801 @default.
- W2548164586 cites W2023683272 @default.
- W2548164586 cites W2026701024 @default.
- W2548164586 cites W2029703586 @default.
- W2548164586 cites W2031188800 @default.
- W2548164586 cites W2031784501 @default.
- W2548164586 cites W2032294121 @default.
- W2548164586 cites W2035123360 @default.
- W2548164586 cites W2038062287 @default.
- W2548164586 cites W2038820792 @default.
- W2548164586 cites W2039261753 @default.
- W2548164586 cites W2041704427 @default.
- W2548164586 cites W2041719399 @default.
- W2548164586 cites W2042404958 @default.
- W2548164586 cites W2044935263 @default.
- W2548164586 cites W2046273251 @default.
- W2548164586 cites W2047462745 @default.
- W2548164586 cites W2047592082 @default.
- W2548164586 cites W2047863993 @default.
- W2548164586 cites W2051685982 @default.
- W2548164586 cites W2052389869 @default.
- W2548164586 cites W2053510668 @default.
- W2548164586 cites W2055746821 @default.
- W2548164586 cites W2056667035 @default.
- W2548164586 cites W2057355419 @default.
- W2548164586 cites W2059329334 @default.
- W2548164586 cites W2062269191 @default.
- W2548164586 cites W2063423463 @default.
- W2548164586 cites W2064101008 @default.
- W2548164586 cites W2064305999 @default.
- W2548164586 cites W2067535022 @default.
- W2548164586 cites W2068359668 @default.
- W2548164586 cites W2071065054 @default.
- W2548164586 cites W2077166822 @default.
- W2548164586 cites W2082154731 @default.
- W2548164586 cites W2083173725 @default.
- W2548164586 cites W2083829293 @default.
- W2548164586 cites W2084112510 @default.
- W2548164586 cites W2088381487 @default.
- W2548164586 cites W2091270126 @default.
- W2548164586 cites W2091628499 @default.
- W2548164586 cites W2093388229 @default.
- W2548164586 cites W2094789916 @default.