FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2548201103> ?p ?o ?g. }

• W2548201103 abstract "Abstract It is well established that activation of Wnt/βcatenin signaling in the osteoblast lineage leads to an increase in bone mass through a dual mechanism: increased osteoblastogenesis and decreased osteoclastogenesis. However, the effect of this pathway on the osteoclast lineage has been less explored. Here, we aimed to examine the effects of Wnt/βcatenin signaling in mature osteoclasts by generating mice lacking βcatenin in CathepsinK -expressing cells ( Ctnnb1 f/f ;CtsKCre mice). These mice developed a severe low-bone-mass phenotype with onset in the second month and in correlation with an excessive number of osteoclasts, detected by TRAP staining and histomorphometric quantification. We found that WNT3A, through the canonical pathway, promoted osteoclast apoptosis and therefore attenuated the number of M-CSF and RANKL-derived osteoclasts in vitro . This reveals a cell-autonomous effect of Wnt/βcatenin signaling in controlling the life span of mature osteoclasts. Furthermore, bone Opg expression in Ctnnb1 f/f ;CtsKCre mice was dramatically decreased pointing to an additional external activation of osteoclasts. Accordingly, expression of CathepsinK was detected in TRAP-negative cells of the inner periosteal layer also expressing Col1 . Our results indicate that the bone phenotype of Ctnnb1 f/f ;CtsKCre animals combines a cell-autonomous effect in the mature osteoclast with indirect effects due to the additional targeting of osteoblastic cells." @default.
• W2548201103 created "2016-11-11" @default.
• W2548201103 creator A5038743486 @default.
• W2548201103 creator A5040245039 @default.
• W2548201103 creator A5042458146 @default.
• W2548201103 creator A5056521347 @default.
• W2548201103 creator A5073329033 @default.
• W2548201103 creator A5089682216 @default.
• W2548201103 date "2016-11-02" @default.
• W2548201103 modified "2023-10-18" @default.
• W2548201103 title "CathepsinKCre mediated deletion of βcatenin results in dramatic loss of bone mass by targeting both osteoclasts and osteoblastic cells" @default.
• W2548201103 cites W1483573741 @default.
• W2548201103 cites W1595293335 @default.
• W2548201103 cites W1595811193 @default.
• W2548201103 cites W1826012123 @default.
• W2548201103 cites W1927572613 @default.
• W2548201103 cites W1972623289 @default.
• W2548201103 cites W1976329877 @default.
• W2548201103 cites W1981284961 @default.
• W2548201103 cites W1982234235 @default.
• W2548201103 cites W1984965767 @default.
• W2548201103 cites W1988019879 @default.
• W2548201103 cites W1988654486 @default.
• W2548201103 cites W1991536018 @default.
• W2548201103 cites W1991959472 @default.
• W2548201103 cites W1994737927 @default.
• W2548201103 cites W1999322873 @default.
• W2548201103 cites W2000682075 @default.
• W2548201103 cites W2003054685 @default.
• W2548201103 cites W2003764631 @default.
• W2548201103 cites W2013293643 @default.
• W2548201103 cites W2014362480 @default.
• W2548201103 cites W2019196925 @default.
• W2548201103 cites W2025059729 @default.
• W2548201103 cites W2040861999 @default.
• W2548201103 cites W2042221627 @default.
• W2548201103 cites W2045808113 @default.
• W2548201103 cites W2081379880 @default.
• W2548201103 cites W2082332913 @default.
• W2548201103 cites W2084075462 @default.
• W2548201103 cites W2086022585 @default.
• W2548201103 cites W2086694435 @default.
• W2548201103 cites W2091450174 @default.
• W2548201103 cites W2092125592 @default.
• W2548201103 cites W2093932892 @default.
• W2548201103 cites W2103597610 @default.
• W2548201103 cites W2104298758 @default.
• W2548201103 cites W2107277218 @default.
• W2548201103 cites W2107311921 @default.
• W2548201103 cites W2107326562 @default.
• W2548201103 cites W2117025246 @default.
• W2548201103 cites W2119413986 @default.
• W2548201103 cites W2120642348 @default.
• W2548201103 cites W2125606512 @default.
• W2548201103 cites W2146138547 @default.
• W2548201103 cites W2148311963 @default.
• W2548201103 cites W2156338697 @default.
• W2548201103 cites W2163341100 @default.
• W2548201103 cites W2192080449 @default.
• W2548201103 cites W2311381469 @default.
• W2548201103 doi "https://doi.org/10.1038/srep36201" @default.
• W2548201103 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5090355" @default.
• W2548201103 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27804995" @default.
• W2548201103 hasPublicationYear "2016" @default.
• W2548201103 type Work @default.
• W2548201103 sameAs 2548201103 @default.
• W2548201103 citedByCount "21" @default.
• W2548201103 countsByYear W25482011032017 @default.
• W2548201103 countsByYear W25482011032018 @default.
• W2548201103 countsByYear W25482011032019 @default.
• W2548201103 countsByYear W25482011032020 @default.
• W2548201103 countsByYear W25482011032021 @default.
• W2548201103 countsByYear W25482011032022 @default.
• W2548201103 countsByYear W25482011032023 @default.
• W2548201103 crossrefType "journal-article" @default.
• W2548201103 hasAuthorship W2548201103A5038743486 @default.
• W2548201103 hasAuthorship W2548201103A5040245039 @default.
• W2548201103 hasAuthorship W2548201103A5042458146 @default.
• W2548201103 hasAuthorship W2548201103A5056521347 @default.
• W2548201103 hasAuthorship W2548201103A5073329033 @default.
• W2548201103 hasAuthorship W2548201103A5089682216 @default.
• W2548201103 hasBestOaLocation W25482011031 @default.
• W2548201103 hasConcept C104317684 @default.
• W2548201103 hasConcept C127716648 @default.
• W2548201103 hasConcept C137620995 @default.
• W2548201103 hasConcept C185592680 @default.
• W2548201103 hasConcept C190283241 @default.
• W2548201103 hasConcept C202751555 @default.
• W2548201103 hasConcept C2776033226 @default.
• W2548201103 hasConcept C2778260815 @default.
• W2548201103 hasConcept C2779131293 @default.
• W2548201103 hasConcept C2779324961 @default.
• W2548201103 hasConcept C2779428903 @default.
• W2548201103 hasConcept C30145163 @default.
• W2548201103 hasConcept C502942594 @default.
• W2548201103 hasConcept C55493867 @default.
• W2548201103 hasConcept C62478195 @default.
• W2548201103 hasConcept C86803240 @default.
• W2548201103 hasConcept C88045685 @default.
• W2548201103 hasConcept C95444343 @default.

• next