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- W2548236072 abstract "Recent studies have established resident memory T cells (TRM ) as the dominant memory lymphocyte population surveying most nonlymphoid tissues. Unlike other memory T cell lineages, TRM do not recirculate through blood and are permanently confined to their tissue of residence. TRM orchestrate local immune responses and have been shown to accelerate local pathogen control in many experimental infection models. Here we briefly summarize recent advances in TRM differentiation, maintenance, and their protective function. While little is known, we have speculated on the potential implications of TRM for transplantation biology. Areas of emphasis include the role of passenger TRM in controlling latent viral recrudescence in donor organs, donor TRM as a source of graft-versus-host disease, the ability of TRM to potently induce inflammation through sensing and alarm functions, and differentiation of host T cells into TRM in response to local cues inside the allograft. Further investigation of TRM in the context of transplantation might identify therapeutic targets to prolong graft survival." @default.
- W2548236072 created "2016-11-11" @default.
- W2548236072 creator A5014214867 @default.
- W2548236072 creator A5050735501 @default.
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- W2548236072 date "2016-12-09" @default.
- W2548236072 modified "2023-10-17" @default.
- W2548236072 title "Implications of Resident Memory T Cells for Transplantation" @default.
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- W2548236072 doi "https://doi.org/10.1111/ajt.14101" @default.
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