FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2548292511> ?p ?o ?g. }

• W2548292511 abstract "Sutherlandia frutescens (L.) R. Br (Lessertia frutescens) is a medicinal plant traditionally used in southern Africa. It has been used for patients suffering from numerous types of cancer, infectious diseases, and various inflammatory conditions. This study was designed to determine the impact of S. frutescens on the inflammatory response and anti-microbial activities on cell and/or animal models. Aqueous and ethanolic extracts of S. frutescens were made and verified using HPLC. These extracts were used to treat murine macrophages (e.g., RAW 264.7 cells and primary macrophages isolated from mice) to evaluate the impact of S. frutescens on in vitro inflammatory responses. This study found that the aqueous extract and a polysaccharide-enriched fraction from the aqueous extract exhibited an immuno-stimulatory activity on murine macrophages. Treatment with aqueous extract or polysaccharides increased the production of reactive oxygen species (ROS), nitric oxide (NO), and inflammatory cytokines/chemokines via activating the toll-like receptor 4 signaling pathway. On the other hand, the ethanolic extract of S. frutescens dose-dependently decreased the production of ROS, NO, inducible nitric oxide synthase (iNOS), and various inflammatory cytokines and chemokines in murine macrophages co-stimulated with lipopolysaccharide (LPS) and interferon gamma (IFNy). Follow up experiments demonstrated that the anti-inflammatory activity of the ethanolic extract was mediated via reductions in the activation of NF-kB, extracellular-signal-regulated kinase 1/2 (ERK1/2), and signal transducers and activators of transcription 1 (STAT1). RNA sequencing provided more evidences to support the anti-inflammatory activity of the ethanolic extract of S. frutescens. To our surprise, chlorophylls isolated from S. frutescens had a greater effect on the anti-inflammatory of S. frutescens than that of unique compounds (i.e., sutherlandiosides and sutherlandins). To investigate the impact of oral consumption of S. frutescens on in vivo inflammatory responses and anti-microbial activities, mice were fed with AIN-93G based diet with/without containing ground S. frutescens powder or were gavaged with S. frutescens extracts followed by challenge with E. coli or LPS. These experiments found that oral consumption of S. frutescens had limited or no impact on the in vivo inflammatory responses and anti-microbial activities. Overall, this study provide a better understanding on the beneficial therapeutic properties of S. frutescens using in vitro models, however these studies in a laboratory mouse model suggest that consumption of S. frutescens had only a modest impact on host anti-microbial and inflammatory responses to a gram-negative microbial challenge whether intact microbes or bacterial endotoxin (i.e., LPS) was used." @default.
• W2548292511 created "2016-11-11" @default.
• W2548292511 creator A5028253155 @default.
• W2548292511 date "2021-04-14" @default.
• W2548292511 modified "2023-10-17" @default.
• W2548292511 title "Modulation of inflammatory responses by Sutherlandia frutescens" @default.
• W2548292511 cites W1483162601 @default.
• W2548292511 cites W1493408017 @default.
• W2548292511 cites W1545016281 @default.
• W2548292511 cites W1556033423 @default.
• W2548292511 cites W1562758188 @default.
• W2548292511 cites W1600472471 @default.
• W2548292511 cites W1834041853 @default.
• W2548292511 cites W1841952269 @default.
• W2548292511 cites W1850593534 @default.
• W2548292511 cites W1940255384 @default.
• W2548292511 cites W1965594477 @default.
• W2548292511 cites W1965840687 @default.
• W2548292511 cites W1966680360 @default.
• W2548292511 cites W1968455762 @default.
• W2548292511 cites W1969477241 @default.
• W2548292511 cites W1971701051 @default.
• W2548292511 cites W1972449088 @default.
• W2548292511 cites W1972724111 @default.
• W2548292511 cites W1972954733 @default.
• W2548292511 cites W1973063723 @default.
• W2548292511 cites W1973376761 @default.
• W2548292511 cites W1973443738 @default.
• W2548292511 cites W1974016956 @default.
• W2548292511 cites W1974189796 @default.
• W2548292511 cites W1976987509 @default.
• W2548292511 cites W1980220254 @default.
• W2548292511 cites W1980248904 @default.
• W2548292511 cites W1981509058 @default.
• W2548292511 cites W1982538571 @default.
• W2548292511 cites W1983024220 @default.
• W2548292511 cites W1983688604 @default.
• W2548292511 cites W1989957948 @default.
• W2548292511 cites W1990065094 @default.
• W2548292511 cites W1990346983 @default.
• W2548292511 cites W1991952977 @default.
• W2548292511 cites W1993211211 @default.
• W2548292511 cites W1993916423 @default.
• W2548292511 cites W1994694127 @default.
• W2548292511 cites W1995744610 @default.
• W2548292511 cites W1996402478 @default.
• W2548292511 cites W1996989522 @default.
• W2548292511 cites W1999718232 @default.
• W2548292511 cites W2001601251 @default.
• W2548292511 cites W2001848039 @default.
• W2548292511 cites W2002047195 @default.
• W2548292511 cites W2002642221 @default.
• W2548292511 cites W2005659566 @default.
• W2548292511 cites W2006553694 @default.
• W2548292511 cites W2006833347 @default.
• W2548292511 cites W2007597115 @default.
• W2548292511 cites W2010539619 @default.
• W2548292511 cites W2013584765 @default.
• W2548292511 cites W2015544673 @default.
• W2548292511 cites W2019029276 @default.
• W2548292511 cites W2021618744 @default.
• W2548292511 cites W2022363372 @default.
• W2548292511 cites W2022943509 @default.
• W2548292511 cites W2024938615 @default.
• W2548292511 cites W2026700800 @default.
• W2548292511 cites W2031406225 @default.
• W2548292511 cites W2031612442 @default.
• W2548292511 cites W2032445654 @default.
• W2548292511 cites W2033232098 @default.
• W2548292511 cites W2036832724 @default.
• W2548292511 cites W2037256135 @default.
• W2548292511 cites W2038689279 @default.
• W2548292511 cites W2038773971 @default.
• W2548292511 cites W2040248263 @default.
• W2548292511 cites W2042087846 @default.
• W2548292511 cites W2043204173 @default.
• W2548292511 cites W2043267841 @default.
• W2548292511 cites W2046178192 @default.
• W2548292511 cites W2046916629 @default.
• W2548292511 cites W2047512700 @default.
• W2548292511 cites W2048486951 @default.
• W2548292511 cites W2050345155 @default.
• W2548292511 cites W2050600674 @default.
• W2548292511 cites W2051061580 @default.
• W2548292511 cites W2051179336 @default.
• W2548292511 cites W2054961655 @default.
• W2548292511 cites W2055348159 @default.
• W2548292511 cites W2055426473 @default.
• W2548292511 cites W2056176542 @default.
• W2548292511 cites W2056812842 @default.
• W2548292511 cites W2056912730 @default.
• W2548292511 cites W2058118671 @default.
• W2548292511 cites W2058335181 @default.
• W2548292511 cites W2058759262 @default.
• W2548292511 cites W2059106230 @default.
• W2548292511 cites W2060630008 @default.
• W2548292511 cites W2060968567 @default.
• W2548292511 cites W2064206070 @default.
• W2548292511 cites W2064299429 @default.
• W2548292511 cites W2064419492 @default.

• next