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- W2548369000 abstract "Summary Purpose Nicotinamide N-methyltransferase (NNMT) plays important roles in energy metabolism and in numerous non-infectious chronic diseases (NCD). The aim of this paper is to observe the influence of the different energy metabolism types on the NNMT expression, which is helpful to understand the roles of NNMT in energy metabolism and to develop exercise therapies against NCD. Methods Thirty Sprague-Dawley rats were randomly distributed into three groups, the control group (CG), the below lactate threshold (LT) group (BLTG) and the supra lactate threshold group (SLTG), and then a 6-week run training program was performed. Before the formal training, the blood lactate of the rats was measured immediately after a 30 min continuous running. Twenty-four hours after the last training session, the extensor digitorum longus muscle (EDL) and the soleus muscles were isolated for analysis of western blot. Results The blood lactate level of the BLTG is only slightly higher than that of the CG (P > 0.05), but that of the SLTG is highly significantly higher than that of the CG or of the BLTG (P Conclusion The glycolytic metabolism is significantly more effective to increase the NNMT expression than the aerobic metabolism, and the anaerobic exercise relying on the glycolytic metabolism system could be used to increase the NNMT expression." @default.
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- W2548369000 date "2017-02-01" @default.
- W2548369000 modified "2023-09-27" @default.
- W2548369000 title "Influence of exercises using different energy metabolism systems on NNMT expression in different types of skeletal muscle fibers" @default.
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- W2548369000 doi "https://doi.org/10.1016/j.scispo.2016.06.004" @default.
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