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• W2548393124 abstract "The present study has been envisaged to investigate Calotropis gigantea (L.) Dryand (Milkweed; family – Asclepiadaceae) for neuropharmacological activities. The powdered plant material was extracted in a Soxhlet apparatus successively using solvents in order of increasing polarity viz., petroleum ether (60-80oC), chloroform and methanol. Ethyl acetate fraction (EAF) was prepared by partitioning methanol extract with ethyl acetate. A single dose of 2 g/kg of methanol and chloroform extract was administered orally to observe toxicity in mice. The methanol extract (200 or 400 mg/kg, p.o.) and EAF (25 or 50 mg/kg, p.o.) were evaluated for antianxiety, anticonvulsant, antidepressant, sedative, antistress and analgesic activities in mice using well established models viz., elevated plus maze, maximal electroshock test, despair swim test, thiopentone sodium induced sleeping assay, cold swim test and tail immersion test respectively. The methanol extract and EAF of C. gigantea roots exhibited statistically significant antianxiety, anticonvulsant, antidepressant, sedative, antistress and analgesic activities with respect to control, but antianxiety, anticonvulsant and sedative activities were statistically not equivalent to the standard drug. Acute toxicity studies of chloroform extract showed 100% mortality whereas methanol extract showed no sign of lethality in mice. Preliminary phytochemical screening of methanol extract and EAF showed presence of flavonoids as major class of phytoconstituents. As flavonoids play a pivotal role in treating brain disorders, it is suggested that these constituents may be responsible for CNS activities. It is finally concluded that the present studies scientifically validated traditional claims of C. gigantea" @default.
• W2548393124 created "2016-11-11" @default.
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• W2548393124 date "2014-01-01" @default.
• W2548393124 modified "2023-09-24" @default.
• W2548393124 title "Screening of Neuropharmacological Activities of Calotropis gigantea roots" @default.
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