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- W25484009 abstract "The neuropeptides of the cholecystokinin (CCK) group belong to the substances usually referred to as brain-gut neuropeptides. They are synthesized in neurons of the central nervous system, in the peripheral and in the autonomous nervous systems, in endocrine cells (types I, K and A), as well as in the enteric nervous system of the gastro-intestinal tract and of the pancreas. The CCK-group peptides realize their effects via several different mechanisms (Fig. 1): endocrine or neuroendocrine (classic hormonal mechanism)--the peptide, released by the endocrine cell or by the nerve terminal, is carried by the circulation to the remote target organs; paracrine or neuroparacrine--the peptide, released in the intercellular space, reaches the target effector cells via diffusion. Similarly to the classic neurotransmitters, CCK and its analogues could play a neurotransmitter role, also modulating the release of acetylcholine (ACh) and of other neurotransmitters in enteric and CNS neurons. In the present review article some smooth-muscle and neuromodulatory effects of CCK are described and compared to the results of the authors' studies on the problem." @default.
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- W25484009 date "1998-01-01" @default.
- W25484009 modified "2023-09-23" @default.
- W25484009 title "Neuropeptides of the cholecystokinin group: effects and mechanisms of action on the gastro-intestinal and gall bladder motility." @default.
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