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• W2548448257 endingPage "12676" @default.
• W2548448257 startingPage "12661" @default.
• W2548448257 abstract "Cytoplasmic polyadenylation element binding protein 2 (CPEB2) is an RNA-binding protein and translational regulator. To understand the physiological function of CPEB2, we generated CPEB2 knock-out (KO) mice and found that most died within 3 d after birth. CPEB2 is highly expressed in the brainstem, which controls vital functions, such as breathing. Whole-body plethysmography revealed that KO neonates had aberrant respiration with frequent apnea. Nevertheless, the morphology and function of the respiratory rhythm generator and diaphragm neuromuscular junctions appeared normal. We found that upregulated translation of choline acetyltransferase in the CPEB2 KO dorsal motor nucleus of vagus resulted in hyperactivation of parasympathetic signaling-induced bronchoconstriction, as evidenced by increased pulmonary acetylcholine and phosphorylated myosin light chain 2 in bronchial smooth muscles. Specific deletion of CPEB2 in cholinergic neurons sufficiently caused increased apnea in neonatal pups and airway hyper-reactivity in adult mice. Moreover, inhalation of an anticholinergic bronchodilator reduced apnea episodes in global and cholinergic CPEB2-KO mice. Together, the elevated airway constriction induced by cholinergic transmission in KO neonates may account for the respiratory defect and mortality. SIGNIFICANCE STATEMENT This study first generated and characterized cpeb2 gene-deficient mice. CPEB2-knock-out (KO) mice are born alive but most die within 3 d after birth showing no overt defects in anatomy. We found that the KO neonates showed severe apnea and altered respiratory pattern. Such respiratory defects could be recapitulated in mice with pan-neuron-specific or cholinergic neuron-specific ablation of the cpeb2 gene. Further investigation revealed that cholinergic transmission in the KO dorsal motor nucleus of vagus was overactivated because KO mice lack CPEB2-suppressed translation of the rate-limiting enzyme in the production of acetylcholine (i.e., choline acetyltransferase). Consequently, increased parasympathetic signaling leads to hyperactivated bronchoconstriction and abnormal respiration in the KO neonates." @default.
• W2548448257 created "2016-11-11" @default.
• W2548448257 creator A5008570342 @default.
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• W2548448257 date "2016-11-03" @default.
• W2548448257 modified "2023-10-09" @default.
• W2548448257 title "Deficiency of CPEB2-Confined Choline Acetyltransferase Expression in the Dorsal Motor Nucleus of Vagus Causes Hyperactivated Parasympathetic Signaling-Associated Bronchoconstriction" @default.
• W2548448257 cites W1481622612 @default.
• W2548448257 cites W1562824548 @default.
• W2548448257 cites W1565758075 @default.
• W2548448257 cites W1568556641 @default.
• W2548448257 cites W1663608651 @default.
• W2548448257 cites W17595264 @default.
• W2548448257 cites W1911973975 @default.
• W2548448257 cites W1969169860 @default.
• W2548448257 cites W1969658378 @default.
• W2548448257 cites W1974172485 @default.
• W2548448257 cites W1974815906 @default.
• W2548448257 cites W1981907698 @default.
• W2548448257 cites W1984930965 @default.
• W2548448257 cites W1986430429 @default.
• W2548448257 cites W1993162037 @default.
• W2548448257 cites W1995579155 @default.
• W2548448257 cites W1996508381 @default.
• W2548448257 cites W1997071887 @default.
• W2548448257 cites W2003230246 @default.
• W2548448257 cites W20054962 @default.
• W2548448257 cites W2007860313 @default.
• W2548448257 cites W2009159343 @default.
• W2548448257 cites W2009601816 @default.
• W2548448257 cites W2017588295 @default.
• W2548448257 cites W2021296682 @default.
• W2548448257 cites W2024465052 @default.
• W2548448257 cites W2026162604 @default.
• W2548448257 cites W2026892351 @default.
• W2548448257 cites W2027970973 @default.
• W2548448257 cites W2029373941 @default.
• W2548448257 cites W2037688283 @default.
• W2548448257 cites W2039586729 @default.
• W2548448257 cites W2040514438 @default.
• W2548448257 cites W2042252670 @default.
• W2548448257 cites W2044199827 @default.
• W2548448257 cites W2060036923 @default.
• W2548448257 cites W2060761548 @default.
• W2548448257 cites W2062517117 @default.
• W2548448257 cites W2073285280 @default.
• W2548448257 cites W2074778674 @default.
• W2548448257 cites W2075930546 @default.
• W2548448257 cites W2079184328 @default.
• W2548448257 cites W2083589781 @default.
• W2548448257 cites W2083694208 @default.
• W2548448257 cites W2085163415 @default.
• W2548448257 cites W2091740202 @default.
• W2548448257 cites W2094151119 @default.
• W2548448257 cites W2094954217 @default.
• W2548448257 cites W2096470603 @default.
• W2548448257 cites W2101369865 @default.
• W2548448257 cites W2102632295 @default.
• W2548448257 cites W2103332846 @default.
• W2548448257 cites W2106587680 @default.
• W2548448257 cites W2107996941 @default.
• W2548448257 cites W2108710130 @default.
• W2548448257 cites W2120094210 @default.
• W2548448257 cites W2124360135 @default.
• W2548448257 cites W2128430188 @default.
• W2548448257 cites W2128492799 @default.
• W2548448257 cites W2131217017 @default.
• W2548448257 cites W2132088145 @default.
• W2548448257 cites W2133797128 @default.
• W2548448257 cites W2134128343 @default.
• W2548448257 cites W2155232620 @default.
• W2548448257 cites W2160966356 @default.
• W2548448257 cites W2161248383 @default.
• W2548448257 cites W2161467344 @default.
• W2548448257 cites W2166627101 @default.
• W2548448257 cites W2169486501 @default.
• W2548448257 cites W2175854707 @default.
• W2548448257 cites W2345153016 @default.
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• W2548448257 doi "https://doi.org/10.1523/jneurosci.0557-16.2016" @default.
• W2548448257 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6705661" @default.
• W2548448257 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27810937" @default.
• W2548448257 hasPublicationYear "2016" @default.
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