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• W2548492971 abstract "Abdominal and thoracic [ <sup xmlns:mml=http://www.w3.org/1998/Math/MathML xmlns:xlink=http://www.w3.org/1999/xlink>18</sup> F]FDG PET/CT imaging is routinely used in clinical practice and drug development but parametric imaging based on full kinetic analysis is rarely used due to noise induced bias and variance in kinetic parameters and analysis is usually restricted to semi-quantitative indices. Direct parametric estimation using 4D image reconstruction can potentially provide parametric maps of reduced bias and variance but little or no evaluation has been done in the body. Previous studies have demonstrated that body [ <sup xmlns:mml=http://www.w3.org/1998/Math/MathML xmlns:xlink=http://www.w3.org/1999/xlink>18</sup> F]FDG PET/CT imaging can benefit from these methods but analysis was restricted to macroparameters of interest. In work, we implement and apply a recently proposed direct 4-D algorithm using a 2 tissue compartment model on simulated and real oncology [ <sup xmlns:mml=http://www.w3.org/1998/Math/MathML xmlns:xlink=http://www.w3.org/1999/xlink>18</sup> F]FDG PET/CT data to directly estimate microparameters of interest and assess potential improvements over the traditional post-reconstruction kinetic analysis. Results on the simulated data suggest clear reduction in bias for K <sub xmlns:mml=http://www.w3.org/1998/Math/MathML xmlns:xlink=http://www.w3.org/1999/xlink>1</sub> , k <sub xmlns:mml=http://www.w3.org/1998/Math/MathML xmlns:xlink=http://www.w3.org/1999/xlink>2</sub> and blood volume and less for k <sub xmlns:mml=http://www.w3.org/1998/Math/MathML xmlns:xlink=http://www.w3.org/1999/xlink>3</sub> . Similarly, variance reduction was observed for K <sub xmlns:mml=http://www.w3.org/1998/Math/MathML xmlns:xlink=http://www.w3.org/1999/xlink>1</sub> , k <sub xmlns:mml=http://www.w3.org/1998/Math/MathML xmlns:xlink=http://www.w3.org/1999/xlink>2</sub> , k <sub xmlns:mml=http://www.w3.org/1998/Math/MathML xmlns:xlink=http://www.w3.org/1999/xlink>3</sub> and K <sub xmlns:mml=http://www.w3.org/1998/Math/MathML xmlns:xlink=http://www.w3.org/1999/xlink>i</sub> and less for blood volume. Evaluation on patient data demonstrated similar improvements using the direct 4-D method in agreement with simulations." @default.
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• W2548492971 date "2012-10-01" @default.
• W2548492971 modified "2023-10-16" @default.
• W2548492971 title "Direct parametric reconstruction for dynamic [¹⁸F]-FDG PET/CT imaging in the body" @default.
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• W2548492971 doi "https://doi.org/10.1109/nssmic.2012.6551770" @default.
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