FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2548567537> ?p ?o ?g. }

• W2548567537 endingPage "731" @default.
• W2548567537 startingPage "723" @default.
• W2548567537 abstract "Akt is a serine/threonine protein kinase, a critical mediator of growth factor-induced survival in key cellular pathways. Allosteric signaling between protein intramolecular domains requires long-range communication mediated by hotspot residues, often triggered by ligand binding. Here, based on extensive 3 μs explicit solvent molecular dynamics (MD) simulations of Akt1 kinase domain in the unbound (apo) and ATP-competitive inhibitor, GDC-0068-bound states, we propose a molecular mechanism for allosteric regulation of Akt1 kinase phosphorylation by GDC-0068 binding to the ATP-binding site. MD simulations revealed that the apo Akt1 is flexible with two disengaged N- and C-lobes, equilibrated between the open and closed conformations. GDC-0068 occupancy of the ATP-binding site shifts the conformational equilibrium of Akt1 from the open conformation toward the closed conformation and stabilizes the closed state. This effect enables allosteric signal propagation from the GDC-0068 to the phosphorylated T308 (pT308) in the activation loop and restrains phosphatase access to pT308, thereby protecting the pT308 in the GDC-0068-bound Akt1. Importantly, functional hotspots involved in the allosteric communication from the GDC-0068 to the pT308 are identified. Our analysis of GDC-0068-induced allosteric protection of Akt kinase phosphorylation yields important new insights into the molecular mechanism of allosteric regulation of Akt kinase activity." @default.
• W2548567537 created "2016-11-11" @default.
• W2548567537 creator A5020551720 @default.
• W2548567537 creator A5047117891 @default.
• W2548567537 creator A5049338114 @default.
• W2548567537 creator A5069849278 @default.
• W2548567537 creator A5071420532 @default.
• W2548567537 creator A5083343856 @default.
• W2548567537 creator A5086671075 @default.
• W2548567537 date "2016-11-24" @default.
• W2548567537 modified "2023-10-05" @default.
• W2548567537 title "Microsecond molecular dynamics simulations provide insight into the ATP-competitive inhibitor-induced allosteric protection of Akt kinase phosphorylation" @default.
• W2548567537 cites W1608710587 @default.
• W2548567537 cites W1908759766 @default.
• W2548567537 cites W1976499671 @default.
• W2548567537 cites W1984621921 @default.
• W2548567537 cites W1988271243 @default.
• W2548567537 cites W1992945955 @default.
• W2548567537 cites W1995254028 @default.
• W2548567537 cites W2000749710 @default.
• W2548567537 cites W2008282782 @default.
• W2548567537 cites W2009364489 @default.
• W2548567537 cites W2010422684 @default.
• W2548567537 cites W2014252415 @default.
• W2548567537 cites W2015714994 @default.
• W2548567537 cites W2018023891 @default.
• W2548567537 cites W2027731629 @default.
• W2548567537 cites W2041205020 @default.
• W2548567537 cites W2054395238 @default.
• W2548567537 cites W2056891806 @default.
• W2548567537 cites W2058768471 @default.
• W2548567537 cites W2067174909 @default.
• W2548567537 cites W2088091011 @default.
• W2548567537 cites W2089617622 @default.
• W2548567537 cites W2090611860 @default.
• W2548567537 cites W2094438068 @default.
• W2548567537 cites W2098707565 @default.
• W2548567537 cites W2103237643 @default.
• W2548567537 cites W2105388112 @default.
• W2548567537 cites W2106140689 @default.
• W2548567537 cites W2108268983 @default.
• W2548567537 cites W2118233996 @default.
• W2548567537 cites W2129006075 @default.
• W2548567537 cites W2134629247 @default.
• W2548567537 cites W2134831715 @default.
• W2548567537 cites W2144288821 @default.
• W2548567537 cites W2147993766 @default.
• W2548567537 cites W2160329145 @default.
• W2548567537 cites W2166875189 @default.
• W2548567537 cites W2195592873 @default.
• W2548567537 cites W2229906614 @default.
• W2548567537 cites W2260312731 @default.
• W2548567537 cites W2262458857 @default.
• W2548567537 cites W2279293113 @default.
• W2548567537 cites W2282990014 @default.
• W2548567537 cites W2286659777 @default.
• W2548567537 cites W2413568519 @default.
• W2548567537 cites W2464027273 @default.
• W2548567537 cites W4238567307 @default.
• W2548567537 cites W4250145027 @default.
• W2548567537 doi "https://doi.org/10.1111/cbdd.12895" @default.
• W2548567537 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27797456" @default.
• W2548567537 hasPublicationYear "2016" @default.
• W2548567537 type Work @default.
• W2548567537 sameAs 2548567537 @default.
• W2548567537 citedByCount "12" @default.
• W2548567537 countsByYear W25485675372018 @default.
• W2548567537 countsByYear W25485675372019 @default.
• W2548567537 countsByYear W25485675372020 @default.
• W2548567537 countsByYear W25485675372021 @default.
• W2548567537 countsByYear W25485675372023 @default.
• W2548567537 crossrefType "journal-article" @default.
• W2548567537 hasAuthorship W2548567537A5020551720 @default.
• W2548567537 hasAuthorship W2548567537A5047117891 @default.
• W2548567537 hasAuthorship W2548567537A5049338114 @default.
• W2548567537 hasAuthorship W2548567537A5069849278 @default.
• W2548567537 hasAuthorship W2548567537A5071420532 @default.
• W2548567537 hasAuthorship W2548567537A5083343856 @default.
• W2548567537 hasAuthorship W2548567537A5086671075 @default.
• W2548567537 hasConcept C104317684 @default.
• W2548567537 hasConcept C11960822 @default.
• W2548567537 hasConcept C12554922 @default.
• W2548567537 hasConcept C143065580 @default.
• W2548567537 hasConcept C154137905 @default.
• W2548567537 hasConcept C159110408 @default.
• W2548567537 hasConcept C166342909 @default.
• W2548567537 hasConcept C181199279 @default.
• W2548567537 hasConcept C184235292 @default.
• W2548567537 hasConcept C185592680 @default.
• W2548567537 hasConcept C32619005 @default.
• W2548567537 hasConcept C41685203 @default.
• W2548567537 hasConcept C55493867 @default.
• W2548567537 hasConcept C71924100 @default.
• W2548567537 hasConcept C75217442 @default.
• W2548567537 hasConcept C86803240 @default.
• W2548567537 hasConcept C95444343 @default.
• W2548567537 hasConceptScore W2548567537C104317684 @default.
• W2548567537 hasConceptScore W2548567537C11960822 @default.

• next