Matches in SemOpenAlex for { <https://semopenalex.org/work/W2548606487> ?p ?o ?g. }
- W2548606487 endingPage "147" @default.
- W2548606487 startingPage "142" @default.
- W2548606487 abstract "Lactoferrin (LF) is a multifunctional cationic protein (pI 8.2-8.9) in mammalian milk. We previously reported that enteric-LF prevented hypercholesterolemia and atherosclerosis in a diet-induced atherosclerosis model using Microminipig, although the underlying mechanisms remain unclear. Because LF is assumed to electrostatically interact with bile acids to inhibit intestinal cholesterol absorption, LF could promote cholesterol excretion. In this study, we assessed the interaction between LF and taurocholate in vitro, and the effect of LF on cholesterol excretion in rats. The binding rate of taurocholate to LF was significantly higher than that to transferrin (pI 5.2-6.3). When rats were administered a high-cholesterol diet (HCD) containing 5% LF, LF was detected using ELISA in the upper small intestine from 7.5 to 60 min after the administration. Rats were fed one of the following diets: control, HCD, or HCD + 5% LF for 21 days. Fecal neutral steroids and hepatic cholesterol levels in the HCD group were significantly higher than those in the control group. The addition of LF to a HCD significantly increased fecal neutral steroids levels (22% increase, p < 0.05) and reduced hepatic cholesterol levels (17% decrease, p < 0.05). These parameters were inversely correlated (R = -0.63, p < 0.05). These results suggest that LF promotes cholesterol excretion via interactions with bile acids." @default.
- W2548606487 created "2016-11-11" @default.
- W2548606487 creator A5010276307 @default.
- W2548606487 creator A5025469685 @default.
- W2548606487 creator A5038813552 @default.
- W2548606487 creator A5048244465 @default.
- W2548606487 creator A5070547574 @default.
- W2548606487 creator A5075581979 @default.
- W2548606487 creator A5080909312 @default.
- W2548606487 creator A5082450673 @default.
- W2548606487 date "2017-02-01" @default.
- W2548606487 modified "2023-10-16" @default.
- W2548606487 title "Lactoferrin interacts with bile acids and increases fecal cholesterol excretion in rats" @default.
- W2548606487 cites W1821638724 @default.
- W2548606487 cites W1823018609 @default.
- W2548606487 cites W1913168986 @default.
- W2548606487 cites W1914396893 @default.
- W2548606487 cites W1956716008 @default.
- W2548606487 cites W1970815707 @default.
- W2548606487 cites W1975585828 @default.
- W2548606487 cites W1982162383 @default.
- W2548606487 cites W1988374679 @default.
- W2548606487 cites W2002986652 @default.
- W2548606487 cites W2028805137 @default.
- W2548606487 cites W2030427706 @default.
- W2548606487 cites W2036275687 @default.
- W2548606487 cites W2037980216 @default.
- W2548606487 cites W2038503219 @default.
- W2548606487 cites W2040704228 @default.
- W2548606487 cites W2041018558 @default.
- W2548606487 cites W2051993916 @default.
- W2548606487 cites W2055265060 @default.
- W2548606487 cites W2059657325 @default.
- W2548606487 cites W2062306329 @default.
- W2548606487 cites W2071897221 @default.
- W2548606487 cites W2074415646 @default.
- W2548606487 cites W2079946012 @default.
- W2548606487 cites W2081371482 @default.
- W2548606487 cites W2090168421 @default.
- W2548606487 cites W2106769458 @default.
- W2548606487 cites W2115052899 @default.
- W2548606487 cites W2123936150 @default.
- W2548606487 cites W2142362907 @default.
- W2548606487 cites W2143486607 @default.
- W2548606487 cites W2149853906 @default.
- W2548606487 cites W2158124451 @default.
- W2548606487 cites W2159534521 @default.
- W2548606487 cites W2162382560 @default.
- W2548606487 cites W2168022629 @default.
- W2548606487 cites W2168526937 @default.
- W2548606487 cites W2170189325 @default.
- W2548606487 cites W2256639710 @default.
- W2548606487 cites W2312314408 @default.
- W2548606487 cites W2314024632 @default.
- W2548606487 cites W4211109054 @default.
- W2548606487 cites W83056796 @default.
- W2548606487 doi "https://doi.org/10.1139/bcb-2016-0052" @default.
- W2548606487 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28165288" @default.
- W2548606487 hasPublicationYear "2017" @default.
- W2548606487 type Work @default.
- W2548606487 sameAs 2548606487 @default.
- W2548606487 citedByCount "13" @default.
- W2548606487 countsByYear W25486064872017 @default.
- W2548606487 countsByYear W25486064872018 @default.
- W2548606487 countsByYear W25486064872019 @default.
- W2548606487 countsByYear W25486064872020 @default.
- W2548606487 countsByYear W25486064872021 @default.
- W2548606487 countsByYear W25486064872022 @default.
- W2548606487 countsByYear W25486064872023 @default.
- W2548606487 crossrefType "journal-article" @default.
- W2548606487 hasAuthorship W2548606487A5010276307 @default.
- W2548606487 hasAuthorship W2548606487A5025469685 @default.
- W2548606487 hasAuthorship W2548606487A5038813552 @default.
- W2548606487 hasAuthorship W2548606487A5048244465 @default.
- W2548606487 hasAuthorship W2548606487A5070547574 @default.
- W2548606487 hasAuthorship W2548606487A5075581979 @default.
- W2548606487 hasAuthorship W2548606487A5080909312 @default.
- W2548606487 hasAuthorship W2548606487A5082450673 @default.
- W2548606487 hasBestOaLocation W25486064872 @default.
- W2548606487 hasConcept C10146269 @default.
- W2548606487 hasConcept C126322002 @default.
- W2548606487 hasConcept C134018914 @default.
- W2548606487 hasConcept C151730666 @default.
- W2548606487 hasConcept C185592680 @default.
- W2548606487 hasConcept C22814914 @default.
- W2548606487 hasConcept C2778163477 @default.
- W2548606487 hasConcept C2779170986 @default.
- W2548606487 hasConcept C2779399885 @default.
- W2548606487 hasConcept C55493867 @default.
- W2548606487 hasConcept C61716771 @default.
- W2548606487 hasConcept C71924100 @default.
- W2548606487 hasConcept C86803240 @default.
- W2548606487 hasConceptScore W2548606487C10146269 @default.
- W2548606487 hasConceptScore W2548606487C126322002 @default.
- W2548606487 hasConceptScore W2548606487C134018914 @default.
- W2548606487 hasConceptScore W2548606487C151730666 @default.
- W2548606487 hasConceptScore W2548606487C185592680 @default.
- W2548606487 hasConceptScore W2548606487C22814914 @default.