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• W2548609966 abstract "Aquaporins (AQP) are transmembrane proteins that provide channels for water and solutes, and some are involved in tumor progression and invasion. We evaluated the expression of AQP-1, AQP-3, and AQP-5 and their clinicopathological significance in prostate adenocarcinomas (PCA). Prostatectomy specimens (n = 99) were retrieved from the surgical pathology archives and clinicopathological data were obtained from the medical database at Kyungpook National University Hospital. Immunohistochemical staining for AQP-1, AQP-3, and AQP-5 was performed on tissue microarrays comprising paired malignant and benign prostatic tissues. Seventeen PCA cases (17.2 %) showed AQP-1 overexpression, specifically 7 tumors (9.7 %) with lower Gleason scores (GS) and 10 tumors (37.0 %) with higher GS, with statistical significance (P = 0.001). AQP-1 overexpression was significantly associated with higher GS (P = 0.001), higher pathologic T (pT) stages (P = 0.024), and biochemical recurrence (BR) (P = 0.002). The difference in AQP-3 and AQP-5 expression between neoplastic and non-neoplastic tissues was not established and there were no correlations with clinicopathological parameters. AQP-1 overexpression was evident in tumors with higher GS, it was less evident in tumors with lower GS, and it was associated with BR and a higher pT stage. AQP-1 overexpression is associated with prostate cancer progression." @default.
• W2548609966 created "2016-11-11" @default.
• W2548609966 creator A5065012481 @default.
• W2548609966 creator A5078084956 @default.
• W2548609966 date "2016-11-05" @default.
• W2548609966 modified "2023-09-27" @default.
• W2548609966 title "Overexpression of Aquaporin-1 is a Prognostic Factor for Biochemical Recurrence in Prostate Adenocarcinoma" @default.
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• W2548609966 doi "https://doi.org/10.1007/s12253-016-0145-7" @default.
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• W2548609966 hasPublicationYear "2016" @default.
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