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• W2548643181 abstract "Development of novel DNA gyrase B inhibitors is an important field of antibacterial drug discovery whose aim is to introduce a more effective representative of this mechanistic class into the clinic. In the present study, two new series of Escherichia coli DNA gyrase inhibitors bearing the 4,5-dibromopyrrolamide moiety have been designed and synthesized. 4,5,6,7-Tetrahydrobenzo[1,2-d]thiazole-2,6-diamine derivatives inhibited E. coli DNA gyrase in the submicromolar to low micromolar range (IC50 values between 0.891 and 10.4μM). Their ring-opened analogues, based on the 2-(2-aminothiazol-4-yl)acetic acid scaffold, displayed weaker DNA gyrase inhibition with IC50 values between 15.9 and 169μM. Molecular docking experiments were conducted to study the binding modes of inhibitors." @default.
• W2548643181 created "2016-11-11" @default.
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• W2548643181 date "2017-01-01" @default.
• W2548643181 modified "2023-10-18" @default.
• W2548643181 title "Design, synthesis and biological evaluation of 4,5-dibromo-N-(thiazol-2-yl)-1H-pyrrole-2-carboxamide derivatives as novel DNA gyrase inhibitors" @default.
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• W2548643181 doi "https://doi.org/10.1016/j.bmc.2016.10.038" @default.
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