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• W2548653421 abstract "The aim of this trial was to investigate the influence of a dietetic product consisting of a unique combination of l-arginine with the vitamins B6, folic acid and B12 (Telcor® Arginin plus) on endothelial dysfunction. Subjects aged 40–65 years with mild to moderate blood pressure (BP) elevation not treated with anti-hypertensive drugs were randomly assigned to either the dietetic product (n = 40) or a matching placebo (n = 41) for 3 months with open follow-up for a further 3 months. Postprandial change in endothelial function was assessed using the validated reactive hyperaemia index (RHI) at 3 months compared to the study onset (RHI post–pre, visit 3–visit 1; ΔΔRHI). Secondary parameters included BP and plasma homocysteine concentration. The primary efficacy analysis revealed superiority of the nutritional intervention over placebo (p = 0.0349) in reducing the deterioration of endothelial function. While in the active group ΔΔRHI increased (0.371 ± 0.122), almost no change could be detected in the placebo group (0.031 ± 0.100), thus demonstrating a significant improvement in vascular function in the intervention group. Moreover, the intervention reduced BP and homocysteine levels. Non-serious adverse events were equally distributed in both groups, and none of the events were assessed as possibly intervention-related by the investigators. This trial confirmed the effective and safe use of dietary management with l-arginine in combination with B vitamins. The primary efficacy analysis demonstrated a statistically significant superiority of the combination of l-arginine with B vitamins over placebo in improving and restoring impaired endothelial function and lowering BP in patients with mild to moderate blood pressure elevation." @default.
• W2548653421 created "2016-11-11" @default.
• W2548653421 creator A5006492057 @default.
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• W2548653421 date "2016-11-05" @default.
• W2548653421 modified "2023-10-11" @default.
• W2548653421 title "l-Arginine and B vitamins improve endothelial function in subjects with mild to moderate blood pressure elevation" @default.
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• W2548653421 doi "https://doi.org/10.1007/s00394-016-1342-6" @default.
• W2548653421 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5845626" @default.
• W2548653421 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27817128" @default.
• W2548653421 hasPublicationYear "2016" @default.
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