FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2548658974> ?p ?o ?g. }

• W2548658974 endingPage "926" @default.
• W2548658974 startingPage "918" @default.
• W2548658974 abstract "Summary Autophagy is a major intracellular pathway for the degradation and recycling of cytosolic components. Emerging evidence has demonstrated its crucial role during the embryo development of invertebrates and vertebrates. We recently demonstrated a massive activation of autophagy in Paracentrotus lividus embryos under cadmium stress conditions, and the existence of a temporal relationship between induced autophagy and apoptosis. Although there have been numerous studies on the role of autophagy in the development of different organisms, information on the autophagic process during oogenesis or at the start of development in marine invertebrates is very limited. Here we report our recent data on the occurrence of autophagy at these key phases of development. In order to investigate autophagy trends we performed in vivo assays to detect autophagolysomes, as well as in situ analysis with anti-LC3 antibody to detect autophagosomes before the fusion with lysosomes. From data generated through confocal laser scanning microscopy and quantification of autophagic signals we have drawn several unequivocal conclusions. The results showed a copious and rising number of autophagic organelles that had specific localization. Interestingly the increase in autophagy that occurred just after fertilization has been proved to be crucial for correct initiation of the developmental programme: irreversible developmental delays and morphologic anomalies were induced by short autophagic inhibition. This work focused on the sea urchin model system and corroborates evidence on the need for self-digestion during development, enriching the knowledge on autophagy, a biological mechanism belonging to evolutionarily different organisms." @default.
• W2548658974 created "2016-11-11" @default.
• W2548658974 creator A5030954911 @default.
• W2548658974 creator A5040404924 @default.
• W2548658974 creator A5044982241 @default.
• W2548658974 creator A5053041588 @default.
• W2548658974 creator A5079431270 @default.
• W2548658974 date "2016-11-01" @default.
• W2548658974 modified "2023-10-18" @default.
• W2548658974 title "Autophagy is required for sea urchin oogenesis and early development" @default.
• W2548658974 cites W1499077664 @default.
• W2548658974 cites W1966512666 @default.
• W2548658974 cites W1978833952 @default.
• W2548658974 cites W1990937181 @default.
• W2548658974 cites W1991105254 @default.
• W2548658974 cites W2001566039 @default.
• W2548658974 cites W2005891025 @default.
• W2548658974 cites W2018318551 @default.
• W2548658974 cites W2020278097 @default.
• W2548658974 cites W2025824234 @default.
• W2548658974 cites W2043790677 @default.
• W2548658974 cites W2051940533 @default.
• W2548658974 cites W2053849681 @default.
• W2548658974 cites W2055579389 @default.
• W2548658974 cites W2062186541 @default.
• W2548658974 cites W2067493968 @default.
• W2548658974 cites W2067692987 @default.
• W2548658974 cites W2070543094 @default.
• W2548658974 cites W2077731318 @default.
• W2548658974 cites W2078487972 @default.
• W2548658974 cites W2115381705 @default.
• W2548658974 cites W2125745872 @default.
• W2548658974 cites W2131009459 @default.
• W2548658974 cites W2138443476 @default.
• W2548658974 cites W2143023548 @default.
• W2548658974 cites W2145673083 @default.
• W2548658974 cites W2164778558 @default.
• W2548658974 cites W2177037818 @default.
• W2548658974 cites W2395348190 @default.
• W2548658974 cites W2752326209 @default.
• W2548658974 doi "https://doi.org/10.1017/s0967199416000253" @default.
• W2548658974 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27805546" @default.
• W2548658974 hasPublicationYear "2016" @default.
• W2548658974 type Work @default.
• W2548658974 sameAs 2548658974 @default.
• W2548658974 citedByCount "22" @default.
• W2548658974 countsByYear W25486589742017 @default.
• W2548658974 countsByYear W25486589742018 @default.
• W2548658974 countsByYear W25486589742019 @default.
• W2548658974 countsByYear W25486589742020 @default.
• W2548658974 countsByYear W25486589742021 @default.
• W2548658974 countsByYear W25486589742022 @default.
• W2548658974 crossrefType "journal-article" @default.
• W2548658974 hasAuthorship W2548658974A5030954911 @default.
• W2548658974 hasAuthorship W2548658974A5040404924 @default.
• W2548658974 hasAuthorship W2548658974A5044982241 @default.
• W2548658974 hasAuthorship W2548658974A5053041588 @default.
• W2548658974 hasAuthorship W2548658974A5079431270 @default.
• W2548658974 hasConcept C168240541 @default.
• W2548658974 hasConcept C172269249 @default.
• W2548658974 hasConcept C181199279 @default.
• W2548658974 hasConcept C185592680 @default.
• W2548658974 hasConcept C18903297 @default.
• W2548658974 hasConcept C190283241 @default.
• W2548658974 hasConcept C203522944 @default.
• W2548658974 hasConcept C2776908312 @default.
• W2548658974 hasConcept C2779436081 @default.
• W2548658974 hasConcept C55493867 @default.
• W2548658974 hasConcept C86803240 @default.
• W2548658974 hasConcept C95444343 @default.
• W2548658974 hasConcept C98539663 @default.
• W2548658974 hasConceptScore W2548658974C168240541 @default.
• W2548658974 hasConceptScore W2548658974C172269249 @default.
• W2548658974 hasConceptScore W2548658974C181199279 @default.
• W2548658974 hasConceptScore W2548658974C185592680 @default.
• W2548658974 hasConceptScore W2548658974C18903297 @default.
• W2548658974 hasConceptScore W2548658974C190283241 @default.
• W2548658974 hasConceptScore W2548658974C203522944 @default.
• W2548658974 hasConceptScore W2548658974C2776908312 @default.
• W2548658974 hasConceptScore W2548658974C2779436081 @default.
• W2548658974 hasConceptScore W2548658974C55493867 @default.
• W2548658974 hasConceptScore W2548658974C86803240 @default.
• W2548658974 hasConceptScore W2548658974C95444343 @default.
• W2548658974 hasConceptScore W2548658974C98539663 @default.
• W2548658974 hasIssue "6" @default.
• W2548658974 hasLocation W25486589741 @default.
• W2548658974 hasLocation W25486589742 @default.
• W2548658974 hasOpenAccess W2548658974 @default.
• W2548658974 hasPrimaryLocation W25486589741 @default.
• W2548658974 hasRelatedWork W1851431531 @default.
• W2548658974 hasRelatedWork W1974152703 @default.
• W2548658974 hasRelatedWork W2107429225 @default.
• W2548658974 hasRelatedWork W2127440157 @default.
• W2548658974 hasRelatedWork W2177037818 @default.
• W2548658974 hasRelatedWork W2548658974 @default.
• W2548658974 hasRelatedWork W2584454512 @default.
• W2548658974 hasRelatedWork W2795682982 @default.
• W2548658974 hasRelatedWork W2957721022 @default.

• next