FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2548715201> ?p ?o ?g. }

• W2548715201 abstract "The abnormal epithelial-mesenchymal restorative capacity in idiopathic pulmonary fibrosis (IPF) has been recently associated with an accelerated aging process as a key point for the altered wound healing. The advanced glycation end-products (AGEs) are the consequence of non-enzymatic reactions between lipid and protein with several oxidants in the aging process. The receptor for AGEs (RAGEs) has been implicated in the lung fibrotic process and the alveolar homeostasis. However, this AGE-RAGE aging pathway has been under-explored in IPF. Lung samples from 16 IPF and 9 control patients were obtained through surgical lung biopsy. Differences in AGEs and RAGE expression between both groups were evaluated by RT-PCR, Western blot and immunohistochemistry. The effect of AGEs on cell viability of primary lung fibrotic fibroblasts and alveolar epithelial cells was assessed. Cell transformation of fibrotic fibroblasts cultured into glycated matrices was evaluated in different experimental conditions. Our study demonstrates an increase of AGEs together with a decrease of RAGEs in IPF lungs, compared with control samples. Two specific AGEs involved in aging, pentosidine and Nε-Carboxymethyl lysine, were significantly increased in IPF samples. The immunohistochemistry identified higher staining of AGEs related to extracellular matrix (ECM) proteins and the apical surface of the alveolar epithelial cells (AECs) surrounding fibroblast foci in fibrotic lungs. On the other hand, RAGE location was present at the cell membrane of AECs in control lungs, while it was almost missing in pulmonary fibrotic tissue. In addition, in vitro cultures showed that the effect of AGEs on cell viability was different for AECs and fibrotic fibroblasts. AGEs decreased cell viability in AECs, even at low concentration, while fibroblast viability was less affected. Furthermore, fibroblast to myofibroblast transformation could be enhanced by ECM glycation. All of these findings suggest a possible role of the increased ratio AGEs-RAGEs in IPF, which could be a relevant accelerating aging tissue reaction in the abnormal wound healing of the lung fibrotic process." @default.
• W2548715201 created "2016-11-11" @default.
• W2548715201 creator A5005407696 @default.
• W2548715201 creator A5007506083 @default.
• W2548715201 creator A5023931782 @default.
• W2548715201 creator A5044845270 @default.
• W2548715201 creator A5045451488 @default.
• W2548715201 creator A5055981872 @default.
• W2548715201 creator A5090855537 @default.
• W2548715201 date "2016-11-05" @default.
• W2548715201 modified "2023-10-14" @default.
• W2548715201 title "Increased AGE-RAGE ratio in idiopathic pulmonary fibrosis" @default.
• W2548715201 cites W1481779597 @default.
• W2548715201 cites W1503258737 @default.
• W2548715201 cites W1549965729 @default.
• W2548715201 cites W1593945683 @default.
• W2548715201 cites W1873340286 @default.
• W2548715201 cites W1963783343 @default.
• W2548715201 cites W1969383603 @default.
• W2548715201 cites W1969737413 @default.
• W2548715201 cites W1970120381 @default.
• W2548715201 cites W1973134807 @default.
• W2548715201 cites W1973520713 @default.
• W2548715201 cites W1978165108 @default.
• W2548715201 cites W1979937536 @default.
• W2548715201 cites W1986014108 @default.
• W2548715201 cites W1989321457 @default.
• W2548715201 cites W1996863401 @default.
• W2548715201 cites W1998496077 @default.
• W2548715201 cites W2005033167 @default.
• W2548715201 cites W2006847300 @default.
• W2548715201 cites W2013222907 @default.
• W2548715201 cites W2014208303 @default.
• W2548715201 cites W2021538179 @default.
• W2548715201 cites W2023232745 @default.
• W2548715201 cites W2028703531 @default.
• W2548715201 cites W2045442917 @default.
• W2548715201 cites W2049511305 @default.
• W2548715201 cites W2058765181 @default.
• W2548715201 cites W2060075831 @default.
• W2548715201 cites W2061185456 @default.
• W2548715201 cites W2066982565 @default.
• W2548715201 cites W2073083940 @default.
• W2548715201 cites W2073701433 @default.
• W2548715201 cites W2078213156 @default.
• W2548715201 cites W2082753300 @default.
• W2548715201 cites W2086327676 @default.
• W2548715201 cites W2091499641 @default.
• W2548715201 cites W2102319255 @default.
• W2548715201 cites W2106447864 @default.
• W2548715201 cites W2106785460 @default.
• W2548715201 cites W2109116451 @default.
• W2548715201 cites W2110364092 @default.
• W2548715201 cites W2110499503 @default.
• W2548715201 cites W2117262777 @default.
• W2548715201 cites W2118385532 @default.
• W2548715201 cites W2120480075 @default.
• W2548715201 cites W2121146836 @default.
• W2548715201 cites W2128635158 @default.
• W2548715201 cites W2144578037 @default.
• W2548715201 cites W2145992607 @default.
• W2548715201 cites W2150894134 @default.
• W2548715201 cites W2151644670 @default.
• W2548715201 cites W2155252583 @default.
• W2548715201 cites W2161212383 @default.
• W2548715201 cites W2162175607 @default.
• W2548715201 cites W2166550136 @default.
• W2548715201 cites W2167383172 @default.
• W2548715201 cites W2168524778 @default.
• W2548715201 cites W4249475676 @default.
• W2548715201 doi "https://doi.org/10.1186/s12931-016-0460-2" @default.
• W2548715201 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5097848" @default.
• W2548715201 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27816054" @default.
• W2548715201 hasPublicationYear "2016" @default.
• W2548715201 type Work @default.
• W2548715201 sameAs 2548715201 @default.
• W2548715201 citedByCount "34" @default.
• W2548715201 countsByYear W25487152012017 @default.
• W2548715201 countsByYear W25487152012018 @default.
• W2548715201 countsByYear W25487152012019 @default.
• W2548715201 countsByYear W25487152012020 @default.
• W2548715201 countsByYear W25487152012021 @default.
• W2548715201 countsByYear W25487152012022 @default.
• W2548715201 countsByYear W25487152012023 @default.
• W2548715201 crossrefType "journal-article" @default.
• W2548715201 hasAuthorship W2548715201A5005407696 @default.
• W2548715201 hasAuthorship W2548715201A5007506083 @default.
• W2548715201 hasAuthorship W2548715201A5023931782 @default.
• W2548715201 hasAuthorship W2548715201A5044845270 @default.
• W2548715201 hasAuthorship W2548715201A5045451488 @default.
• W2548715201 hasAuthorship W2548715201A5055981872 @default.
• W2548715201 hasAuthorship W2548715201A5090855537 @default.
• W2548715201 hasBestOaLocation W25487152011 @default.
• W2548715201 hasConcept C126322002 @default.
• W2548715201 hasConcept C142724271 @default.
• W2548715201 hasConcept C147990577 @default.
• W2548715201 hasConcept C169760540 @default.
• W2548715201 hasConcept C170493617 @default.
• W2548715201 hasConcept C189165786 @default.
• W2548715201 hasConcept C204232928 @default.

• next