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• W2548739897 abstract "When developing a novel antibody-drug conjugate (ADC) therapeutic, either an indication-dependent or an indication-independent approach can be used to identify appropriate targets. Many groups have reported preclinical development of trastuzumab-based ADCs utilizing warheads with different activities that may be toxic to slowly proliferating cells, so it is interesting to see if additional toxicities are observed with these ADCs, and in particular if there is increased frequency of cardiotoxicity. Although much of the toxicity observed in ADC clinical trials so far appears to be off-target, on-target toxicity remains a key challenge that must be addressed by careful target selection. Another route to improving the efficacy and safety of ADCs is through combination with other therapies. New approaches to ADC target discovery including phenotypic selection screens and cancer membrane proteomics, and incorporation of new ADC technology innovations such as bispecifics, provide the next frontiers in developing these promising cancer therapies." @default.
• W2548739897 created "2016-11-11" @default.
• W2548739897 creator A5035878833 @default.
• W2548739897 creator A5043496849 @default.
• W2548739897 date "2016-11-03" @default.
• W2548739897 modified "2023-09-23" @default.
• W2548739897 title "Selecting Optimal Antibody-Drug Conjugate Targets Using Indication-Dependent or Indication-Independent Approaches" @default.
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• W2548739897 doi "https://doi.org/10.1002/9781119060727.ch2" @default.
• W2548739897 hasPublicationYear "2016" @default.
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