Matches in SemOpenAlex for { <https://semopenalex.org/work/W2548761413> ?p ?o ?g. }
- W2548761413 endingPage "691" @default.
- W2548761413 startingPage "684" @default.
- W2548761413 abstract "The combined strategy of drug-cyclodextrin (CD) complexation and complex loading into nanocarriers (deformable liposomes or nanostructured lipid carriers (NLC)), was exploited to develop effective topical formulations for oxaprozin transdermal administration. Oxaprozin was loaded as ternary complex with randomly-methylated-ßCD and arginine, selected as the best system in improving drug solubility. The colloidal dispersions, characterized for particle size, zeta-potential and entrapment efficiency, were investigated for drug permeation properties in comparison with a plain drug aqueous suspension, a ternary complex aqueous solution and a plain drug liposomal or NLC dispersion. Experiments with artificial membranes showed that the joined use of CD and both liposomes or NLC enabled a marked increase of the drug permeability (16 and 8 times, respectively) and was significantly more effective (P < 0.05) than the drug as ternary complex (3.2 times increase), and the corresponding liposomal or NLC dispersion of plain drug (5.6 and 4.3 times increase, respectively). Experiments with excised human skin confirmed the significantly (P < 0.05) better performance of deformable liposomes than NLC in promoting drug permeation; moreover, they evidenced a more marked permeability increase compared to the plain drug (24 and 12 fold, respectively), attributed to a possible enhancer effect of the nanocarriers components and/or of the randomly-methylated-ßCD." @default.
- W2548761413 created "2016-11-11" @default.
- W2548761413 creator A5034765310 @default.
- W2548761413 creator A5042287581 @default.
- W2548761413 creator A5050895361 @default.
- W2548761413 creator A5066280195 @default.
- W2548761413 date "2016-12-01" @default.
- W2548761413 modified "2023-09-29" @default.
- W2548761413 title "Comparison of liposomal and NLC (nanostructured lipid carrier) formulations for improving the transdermal delivery of oxaprozin: Effect of cyclodextrin complexation" @default.
- W2548761413 cites W1489657123 @default.
- W2548761413 cites W1575211640 @default.
- W2548761413 cites W1972856288 @default.
- W2548761413 cites W1976939919 @default.
- W2548761413 cites W1992313420 @default.
- W2548761413 cites W1999361556 @default.
- W2548761413 cites W2002418262 @default.
- W2548761413 cites W2014655609 @default.
- W2548761413 cites W2019915434 @default.
- W2548761413 cites W2027462520 @default.
- W2548761413 cites W2028761028 @default.
- W2548761413 cites W2036240221 @default.
- W2548761413 cites W2037176643 @default.
- W2548761413 cites W2040221200 @default.
- W2548761413 cites W2043984175 @default.
- W2548761413 cites W2047817628 @default.
- W2548761413 cites W2050087641 @default.
- W2548761413 cites W2050970046 @default.
- W2548761413 cites W2051544216 @default.
- W2548761413 cites W2051976064 @default.
- W2548761413 cites W2052019998 @default.
- W2548761413 cites W2053070993 @default.
- W2548761413 cites W2055659735 @default.
- W2548761413 cites W2056764794 @default.
- W2548761413 cites W2058009653 @default.
- W2548761413 cites W2061471987 @default.
- W2548761413 cites W2061720944 @default.
- W2548761413 cites W2062652730 @default.
- W2548761413 cites W2073983855 @default.
- W2548761413 cites W2086540068 @default.
- W2548761413 cites W2086889742 @default.
- W2548761413 cites W2094772911 @default.
- W2548761413 cites W2100038111 @default.
- W2548761413 cites W2130169412 @default.
- W2548761413 cites W2138361094 @default.
- W2548761413 cites W2156339880 @default.
- W2548761413 cites W2504579159 @default.
- W2548761413 doi "https://doi.org/10.1016/j.ijpharm.2016.11.013" @default.
- W2548761413 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27825863" @default.
- W2548761413 hasPublicationYear "2016" @default.
- W2548761413 type Work @default.
- W2548761413 sameAs 2548761413 @default.
- W2548761413 citedByCount "43" @default.
- W2548761413 countsByYear W25487614132017 @default.
- W2548761413 countsByYear W25487614132018 @default.
- W2548761413 countsByYear W25487614132019 @default.
- W2548761413 countsByYear W25487614132020 @default.
- W2548761413 countsByYear W25487614132021 @default.
- W2548761413 countsByYear W25487614132022 @default.
- W2548761413 countsByYear W25487614132023 @default.
- W2548761413 crossrefType "journal-article" @default.
- W2548761413 hasAuthorship W2548761413A5034765310 @default.
- W2548761413 hasAuthorship W2548761413A5042287581 @default.
- W2548761413 hasAuthorship W2548761413A5050895361 @default.
- W2548761413 hasAuthorship W2548761413A5066280195 @default.
- W2548761413 hasConcept C13245373 @default.
- W2548761413 hasConcept C155574463 @default.
- W2548761413 hasConcept C155672457 @default.
- W2548761413 hasConcept C171250308 @default.
- W2548761413 hasConcept C178790620 @default.
- W2548761413 hasConcept C18150654 @default.
- W2548761413 hasConcept C184651966 @default.
- W2548761413 hasConcept C185154212 @default.
- W2548761413 hasConcept C185592680 @default.
- W2548761413 hasConcept C192562407 @default.
- W2548761413 hasConcept C205679159 @default.
- W2548761413 hasConcept C2779433975 @default.
- W2548761413 hasConcept C2779820397 @default.
- W2548761413 hasConcept C2780035454 @default.
- W2548761413 hasConcept C41625074 @default.
- W2548761413 hasConcept C43617362 @default.
- W2548761413 hasConcept C50670333 @default.
- W2548761413 hasConcept C55493867 @default.
- W2548761413 hasConcept C71924100 @default.
- W2548761413 hasConcept C86181022 @default.
- W2548761413 hasConcept C98274493 @default.
- W2548761413 hasConceptScore W2548761413C13245373 @default.
- W2548761413 hasConceptScore W2548761413C155574463 @default.
- W2548761413 hasConceptScore W2548761413C155672457 @default.
- W2548761413 hasConceptScore W2548761413C171250308 @default.
- W2548761413 hasConceptScore W2548761413C178790620 @default.
- W2548761413 hasConceptScore W2548761413C18150654 @default.
- W2548761413 hasConceptScore W2548761413C184651966 @default.
- W2548761413 hasConceptScore W2548761413C185154212 @default.
- W2548761413 hasConceptScore W2548761413C185592680 @default.
- W2548761413 hasConceptScore W2548761413C192562407 @default.
- W2548761413 hasConceptScore W2548761413C205679159 @default.
- W2548761413 hasConceptScore W2548761413C2779433975 @default.
- W2548761413 hasConceptScore W2548761413C2779820397 @default.