FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2548763762> ?p ?o ?g. }

• W2548763762 abstract "The presence of tumor-infiltrating lymphocytes (TILs) is a prognostic factor in triple-negative breast cancer (TNBC). Specifically, cytotoxic CD8+ cells are associated with favorable outcome in TNBC. Recently, the integrin CD103 has been suggested as a potential prognostic marker in breast cancer. In this study, we aimed to evaluate the functional status and clinical relevance of CD8+ and CD103+ TILs in TNBC. A retrospective cohort of 210 formalin-fixed, paraffin-embedded tissues from patients with primary invasive ductal TNBC was assessed for the presence of CD8, CD103 and the checkpoint receptor PD-1 by immunohistochemistry assay. Whole tumor slides were assessed. Cases where ≥5% of TILs expressed CD103 or PD-1 were considered positive. Statistical analyses were performed using Spearman9s correlation, Kaplan-Meier and Cox regression analyses. We found that CD103+ cells mostly co-expressed the CD8 marker, and were preferentially distributed within tumor epithelium. No consistent correlation was found between the presence of CD103+ lymphocytes and the expression of its ligand E-cadherin by TNBC cells (rs = 0.365). CD8+ lymphocytes were consistently associated with better relapse-free survival (RFS) and overall survival (OS) in both univariate (HR = 0.61; P = 1.06E-02 for RFS; HR = 0.59; P = 1.93E-02 for OS) and multivariate analysis (HR = 0.65; P = 2.45E-02 for RFS; HR = 0.63; P = 3.96E-02 for OS). The presence of CD103+ lymphocytes significantly correlated with prolonged RFS and OS in univariate analysis only (HR = 0.82; P = 4.12E-02 for RFS; HR = 0.85; P = 4.93E-02 for OS), and a trend for longer RFS was also observed in univariate analysis for PD-1 (HR = 0.71; P = 5.22E-02). Interestingly, a subset of TNBC showed co-expression of CD103+/PD-1+ in lymphocytes localized to the intraepithelial areas of the tumor. The expression of CD103 on CD8+ T cells in direct contact with cancer cells may identify a subpopulation of cells with potent cytolytic activity. The interaction between CD103+ cytotoxic lymphocytes and TNBC cells is mediated by different mechanisms rather than the binding to E-cadherin. Even though CD103 has a role in mediating an effective anti-tumor immune response, its presence alone may not be sufficient to impact the outcome of TNBC patients. Immunomodulatory therapies may be useful to boost the anti-tumor activity of potentially quiescent CD103+/PD-1+ cells in a subgroup of TNBC patients. Citation Format: Giulia Bottai, Massimo Roncalli, Libero Santarpia. CD103+/PD-1+ T-cells identify a subset of triple-negative breast cancer eligible for targeted checkpoint inhibition [abstract]. In: Proceedings of the Second CRI-CIMT-EATI-AACR International Cancer Immunotherapy Conference: Translating Science into Survival; 2016 Sept 25-28; New York, NY. Philadelphia (PA): AACR; Cancer Immunol Res 2016;4(11 Suppl):Abstract nr A118." @default.
• W2548763762 created "2016-11-11" @default.
• W2548763762 creator A5018454361 @default.
• W2548763762 creator A5041255789 @default.
• W2548763762 creator A5041845308 @default.
• W2548763762 date "2016-10-31" @default.
• W2548763762 modified "2023-09-27" @default.
• W2548763762 title "Abstract A118: CD103+/PD-1+ T-cells identify a subset of triple-negative breast cancer eligible for targeted checkpoint inhibition" @default.
• W2548763762 doi "https://doi.org/10.1158/2326-6066.imm2016-a118" @default.
• W2548763762 hasPublicationYear "2016" @default.
• W2548763762 type Work @default.
• W2548763762 sameAs 2548763762 @default.
• W2548763762 citedByCount "0" @default.
• W2548763762 crossrefType "proceedings-article" @default.
• W2548763762 hasAuthorship W2548763762A5018454361 @default.
• W2548763762 hasAuthorship W2548763762A5041255789 @default.
• W2548763762 hasAuthorship W2548763762A5041845308 @default.
• W2548763762 hasConcept C121608353 @default.
• W2548763762 hasConcept C126322002 @default.
• W2548763762 hasConcept C143998085 @default.
• W2548763762 hasConcept C144301174 @default.
• W2548763762 hasConcept C147483822 @default.
• W2548763762 hasConcept C167672396 @default.
• W2548763762 hasConcept C203014093 @default.
• W2548763762 hasConcept C204232928 @default.
• W2548763762 hasConcept C2777701055 @default.
• W2548763762 hasConcept C2778326572 @default.
• W2548763762 hasConcept C2780110267 @default.
• W2548763762 hasConcept C2781053074 @default.
• W2548763762 hasConcept C38180746 @default.
• W2548763762 hasConcept C502942594 @default.
• W2548763762 hasConcept C530470458 @default.
• W2548763762 hasConcept C71924100 @default.
• W2548763762 hasConceptScore W2548763762C121608353 @default.
• W2548763762 hasConceptScore W2548763762C126322002 @default.
• W2548763762 hasConceptScore W2548763762C143998085 @default.
• W2548763762 hasConceptScore W2548763762C144301174 @default.
• W2548763762 hasConceptScore W2548763762C147483822 @default.
• W2548763762 hasConceptScore W2548763762C167672396 @default.
• W2548763762 hasConceptScore W2548763762C203014093 @default.
• W2548763762 hasConceptScore W2548763762C204232928 @default.
• W2548763762 hasConceptScore W2548763762C2777701055 @default.
• W2548763762 hasConceptScore W2548763762C2778326572 @default.
• W2548763762 hasConceptScore W2548763762C2780110267 @default.
• W2548763762 hasConceptScore W2548763762C2781053074 @default.
• W2548763762 hasConceptScore W2548763762C38180746 @default.
• W2548763762 hasConceptScore W2548763762C502942594 @default.
• W2548763762 hasConceptScore W2548763762C530470458 @default.
• W2548763762 hasConceptScore W2548763762C71924100 @default.
• W2548763762 hasLocation W25487637621 @default.
• W2548763762 hasOpenAccess W2548763762 @default.
• W2548763762 hasPrimaryLocation W25487637621 @default.
• W2548763762 hasRelatedWork W1984850374 @default.
• W2548763762 hasRelatedWork W2042875767 @default.
• W2548763762 hasRelatedWork W2122554300 @default.
• W2548763762 hasRelatedWork W2330542762 @default.
• W2548763762 hasRelatedWork W2407489461 @default.
• W2548763762 hasRelatedWork W2559001417 @default.
• W2548763762 hasRelatedWork W2592833514 @default.
• W2548763762 hasRelatedWork W2790356395 @default.
• W2548763762 hasRelatedWork W2896329783 @default.
• W2548763762 hasRelatedWork W2913112329 @default.
• W2548763762 hasRelatedWork W2918671471 @default.
• W2548763762 hasRelatedWork W2972323851 @default.
• W2548763762 hasRelatedWork W2972550474 @default.
• W2548763762 hasRelatedWork W3006180649 @default.
• W2548763762 hasRelatedWork W3006396854 @default.
• W2548763762 hasRelatedWork W3046990190 @default.
• W2548763762 hasRelatedWork W3082802647 @default.
• W2548763762 hasRelatedWork W3083945796 @default.
• W2548763762 hasRelatedWork W3120113310 @default.
• W2548763762 hasRelatedWork W3158544331 @default.
• W2548763762 isParatext "false" @default.
• W2548763762 isRetracted "false" @default.
• W2548763762 magId "2548763762" @default.
• W2548763762 workType "article" @default.