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• W2548826862 abstract "The CCAAT-binding factor CBF/NF-Y is needed for cell proliferation and early embryonic development. NF-Y can regulate the expression of different cell type-specific genes that are activated by various physiological signaling pathways. Dysregulation of NF-Y was observed in pathogenic conditions in humans such as scleroderma, neurodegenerative disease, and cancer. Conditional inactivation of the NF-YA gene in mice demonstrated that NF-Y activity is essential for normal tissue homeostasis, survival, and metabolic function. Altogether, NF-Y is an essential transcription factor that plays a critical role in mammalian development, from the early stages to adulthood, and in human pathogenesis. This article is part of a Special Issue entitled: Nuclear Factor Y in Development and Disease, edited by Prof. Roberto Mantovani." @default.
• W2548826862 created "2016-11-11" @default.
• W2548826862 creator A5085242691 @default.
• W2548826862 date "2017-05-01" @default.
• W2548826862 modified "2023-10-03" @default.
• W2548826862 title "NF-Y (CBF) regulation in specific cell types and mouse models" @default.
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• W2548826862 doi "https://doi.org/10.1016/j.bbagrm.2016.10.014" @default.
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