Matches in SemOpenAlex for { <https://semopenalex.org/work/W2548907591> ?p ?o ?g. }
- W2548907591 endingPage "286" @default.
- W2548907591 startingPage "272" @default.
- W2548907591 abstract "Borrelia burgdorferi, the causative agent of Lyme disease, is capable of forming biofilm in vivo and in vitro, a structure well known for its resistance to antimicrobial agents. For the formation of biofilm, signaling processes are required to communicate with the surrounding environment such as it was shown for the RpoN—RpoS alternative sigma factor and for the LuxS quorum-sensing pathways. Therefore, in this study, the wild-type B. burgdorferi and different mutant strains lacking RpoN, RpoS, and LuxS genes were studied for their growth characteristic and development of biofilm structures and markers as well as for their antibiotic sensitivity. Our results showed that all three mutants formed small, loosely formed aggregates, which expressed previously identified Borrelia biofilm markers such as alginate, extracellular DNA, and calcium. All three mutants had significantly different sensitivity to doxycyline in the early log phase spirochete cultures; however, in the biofilm rich stationary cultures, only LuxS mutant showed increased sensitivity to doxycyline compared to the wild-type strain. Our findings indicate that all three mutants have some effect on Borrelia biofilm, but the most dramatic effect was found with LuxS mutant, suggesting that the quorum-sensing pathway plays an important role of Borrelia biofilm formation and antibiotic sensitivity." @default.
- W2548907591 created "2016-11-11" @default.
- W2548907591 creator A5013063927 @default.
- W2548907591 creator A5016523400 @default.
- W2548907591 creator A5058692031 @default.
- W2548907591 creator A5084513094 @default.
- W2548907591 creator A5086565286 @default.
- W2548907591 date "2016-12-01" @default.
- W2548907591 modified "2023-10-15" @default.
- W2548907591 title "Effect of RpoN, RpoS and LuxS pathways on the biofilm formation and antibiotIc sensitivity of <i>Borrelia burgdorferi</i>" @default.
- W2548907591 cites W1544976575 @default.
- W2548907591 cites W1557420229 @default.
- W2548907591 cites W1880959843 @default.
- W2548907591 cites W1887289367 @default.
- W2548907591 cites W1897572360 @default.
- W2548907591 cites W1918000672 @default.
- W2548907591 cites W1969973578 @default.
- W2548907591 cites W1970064291 @default.
- W2548907591 cites W1980984820 @default.
- W2548907591 cites W1986519128 @default.
- W2548907591 cites W1986683117 @default.
- W2548907591 cites W1986984168 @default.
- W2548907591 cites W1993225808 @default.
- W2548907591 cites W1993369443 @default.
- W2548907591 cites W1995024953 @default.
- W2548907591 cites W2025609755 @default.
- W2548907591 cites W2029366035 @default.
- W2548907591 cites W2037758741 @default.
- W2548907591 cites W2050078027 @default.
- W2548907591 cites W2060779329 @default.
- W2548907591 cites W2061126046 @default.
- W2548907591 cites W2068522004 @default.
- W2548907591 cites W2069186808 @default.
- W2548907591 cites W2070300719 @default.
- W2548907591 cites W2071784720 @default.
- W2548907591 cites W2079698171 @default.
- W2548907591 cites W2087254697 @default.
- W2548907591 cites W2088540532 @default.
- W2548907591 cites W2095291804 @default.
- W2548907591 cites W2096785805 @default.
- W2548907591 cites W2099514604 @default.
- W2548907591 cites W2105144883 @default.
- W2548907591 cites W2112984193 @default.
- W2548907591 cites W2118904459 @default.
- W2548907591 cites W2120695650 @default.
- W2548907591 cites W2121992777 @default.
- W2548907591 cites W2123356751 @default.
- W2548907591 cites W2127310751 @default.
- W2548907591 cites W2130803530 @default.
- W2548907591 cites W2131727615 @default.
- W2548907591 cites W2131869707 @default.
- W2548907591 cites W2136310274 @default.
- W2548907591 cites W2137123557 @default.
- W2548907591 cites W2138134673 @default.
- W2548907591 cites W2138690106 @default.
- W2548907591 cites W2143628550 @default.
- W2548907591 cites W2144440398 @default.
- W2548907591 cites W2144640625 @default.
- W2548907591 cites W2144788204 @default.
- W2548907591 cites W2145655625 @default.
- W2548907591 cites W2146396296 @default.
- W2548907591 cites W2146914791 @default.
- W2548907591 cites W2151001863 @default.
- W2548907591 cites W2151239002 @default.
- W2548907591 cites W2162376398 @default.
- W2548907591 cites W2163533527 @default.
- W2548907591 cites W2163586341 @default.
- W2548907591 cites W2165863543 @default.
- W2548907591 cites W2172004136 @default.
- W2548907591 cites W2180283734 @default.
- W2548907591 cites W2195522236 @default.
- W2548907591 cites W2254366055 @default.
- W2548907591 cites W2273446410 @default.
- W2548907591 cites W2415331636 @default.
- W2548907591 cites W2475057764 @default.
- W2548907591 cites W2997755801 @default.
- W2548907591 doi "https://doi.org/10.1556/1886.2016.00026" @default.
- W2548907591 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5146646" @default.
- W2548907591 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27980856" @default.
- W2548907591 hasPublicationYear "2016" @default.
- W2548907591 type Work @default.
- W2548907591 sameAs 2548907591 @default.
- W2548907591 citedByCount "23" @default.
- W2548907591 countsByYear W25489075912017 @default.
- W2548907591 countsByYear W25489075912018 @default.
- W2548907591 countsByYear W25489075912019 @default.
- W2548907591 countsByYear W25489075912021 @default.
- W2548907591 countsByYear W25489075912022 @default.
- W2548907591 countsByYear W25489075912023 @default.
- W2548907591 crossrefType "journal-article" @default.
- W2548907591 hasAuthorship W2548907591A5013063927 @default.
- W2548907591 hasAuthorship W2548907591A5016523400 @default.
- W2548907591 hasAuthorship W2548907591A5058692031 @default.
- W2548907591 hasAuthorship W2548907591A5084513094 @default.
- W2548907591 hasAuthorship W2548907591A5086565286 @default.
- W2548907591 hasBestOaLocation W25489075911 @default.
- W2548907591 hasConcept C101762097 @default.
- W2548907591 hasConcept C104317684 @default.