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- W2548961910 endingPage "F156" @default.
- W2548961910 startingPage "F143" @default.
- W2548961910 abstract "Within the CCD of the distal nephron of the rabbit, the BK (maxi K) channel mediates Ca 2+ - and/or stretch-dependent flow-induced K + secretion (FIKS) and contributes to K + adaptation in response to dietary K + loading. An unresolved question is whether BK channels in intercalated cells (ICs) and/or principal cells (PCs) in the CCD mediate these K + secretory processes. In support of a role for ICs in FIKS is the higher density of immunoreactive apical BKα (pore-forming subunit) and functional BK channel activity than detected in PCs, and an increase in IC BKα expression in response to a high-K + diet. PCs possess a single apical cilium which has been proposed to serve as a mechanosensor; direct manipulation of cilia leads to increases in cell Ca 2+ concentration, albeit of nonciliary origin. Immunoperfusion of isolated and fixed CCDs isolated from control K + -fed rabbits with channel subunit-specific antibodies revealed colocalization of immunodetectable BKα- and β1-subunits in cilia as well as on the apical membrane of cilia-expressing PCs. Ciliary BK channels were more easily detected in rabbits fed a low-K + vs. high-K + diet. Single-channel recordings of cilia revealed K + channels with conductance and kinetics typical of the BK channel. The observations that 1) FIKS was preserved but 2) the high-amplitude Ca 2+ peak elicited by flow was reduced in microperfused CCDs subject to pharmacological deciliation suggest that cilia BK channels do not contribute to K + secretion in this segment, but that cilia serve as modulators of cell signaling." @default.
- W2548961910 created "2016-11-11" @default.
- W2548961910 creator A5000815865 @default.
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- W2548961910 creator A5032533121 @default.
- W2548961910 creator A5049888042 @default.
- W2548961910 creator A5088195948 @default.
- W2548961910 date "2017-01-01" @default.
- W2548961910 modified "2023-10-18" @default.
- W2548961910 title "The mechanosensitive BKα/β1 channel localizes to cilia of principal cells in rabbit cortical collecting duct (CCD)" @default.
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