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- W2548973834 abstract "With the combination of Pd(dppf)Cl2 and Cu(OAc)2, a variety of 5-iminopyrrolones were synthesized in moderate to good yields from terminal alkynes, isocyanide, and water via isocyanide double insertion and cycloaddition reaction. A plausible reaction mechanism for this process is depicted. Furthermore, selected compounds 3c, 3e, and 3h exhibited good activities against HepG2 (human liver cancer), NCI-H460 (human lung cancer), and SK-OV-3 (human ovarian cancer) cell lines with IC50 values in the range of 10.63-22.63 μmol L-1." @default.
- W2548973834 created "2016-11-11" @default.
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- W2548973834 date "2016-11-09" @default.
- W2548973834 modified "2023-10-15" @default.
- W2548973834 title "Palladium-Catalyzed Synthesis of 5-Iminopyrrolones through Isocyanide Double Insertion Reaction with Terminal Alkynes and Water" @default.
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- W2548973834 doi "https://doi.org/10.1021/acs.joc.6b02288" @default.
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