FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2549071489> ?p ?o ?g. }

• W2549071489 endingPage "87231" @default.
• W2549071489 startingPage "87219" @default.
• W2549071489 abstract "Previous clinical reports have found elevated osteopontin (OPN) levels in tumor tissues to be indicative of greater malignancy in human hepatocellular carcinoma (HCC). However, the role of OPN on carcinogenesis and its underlying mechanism remain unclear. In the present study, we investigated the oncogenic role of OPN in diethylnitrosamine (DEN)-induced hepatic carcinogenesis in mice. The overall incidence of hepatic tumors at 36 weeks was significantly lower in OPN knockout (KO) mice than in wild-type (WT) mice. Apoptosis was significantly enhanced in OPN KO mice, and was accompanied by the downregulation of epidermal growth factor receptor (EGFR). In the in vitro study, OPN suppression also led to lower mRNA and protein levels of EGFR associated with the downregulation of c-Jun in Hep3B and Huh7 human HCC cells lines, which resulted in increased apoptotic cell death in both cell lines. Moreover, a positive correlation was clearly identified between the expression of OPN and EGFR in human HCC tissues. These data demonstrate that the OPN deficiency reduced the incidence of chemically induced HCC by suppressing EGFR-mediated anti-apoptotic signaling. An important implication of our findings is that OPN positively contributes to hepatic carcinogenesis." @default.
• W2549071489 created "2016-11-30" @default.
• W2549071489 creator A5000047091 @default.
• W2549071489 creator A5009893662 @default.
• W2549071489 creator A5011718542 @default.
• W2549071489 creator A5019878183 @default.
• W2549071489 creator A5058785584 @default.
• W2549071489 creator A5063894501 @default.
• W2549071489 creator A5073793918 @default.
• W2549071489 date "2016-11-23" @default.
• W2549071489 modified "2023-10-18" @default.
• W2549071489 title "Suppression of osteopontin inhibits chemically induced hepatic carcinogenesis by induction of apoptosis in mice" @default.
• W2549071489 cites W1515959446 @default.
• W2549071489 cites W1690635788 @default.
• W2549071489 cites W1863772432 @default.
• W2549071489 cites W1965712234 @default.
• W2549071489 cites W1972162901 @default.
• W2549071489 cites W1982114820 @default.
• W2549071489 cites W1999483148 @default.
• W2549071489 cites W2000593366 @default.
• W2549071489 cites W2004908411 @default.
• W2549071489 cites W2010754117 @default.
• W2549071489 cites W2016710415 @default.
• W2549071489 cites W2023725755 @default.
• W2549071489 cites W2025105039 @default.
• W2549071489 cites W2025787635 @default.
• W2549071489 cites W2034144251 @default.
• W2549071489 cites W2039567228 @default.
• W2549071489 cites W2039621565 @default.
• W2549071489 cites W2053202236 @default.
• W2549071489 cites W2057616292 @default.
• W2549071489 cites W2075601071 @default.
• W2549071489 cites W2077981972 @default.
• W2549071489 cites W2079650044 @default.
• W2549071489 cites W2094858991 @default.
• W2549071489 cites W2102759180 @default.
• W2549071489 cites W2105932025 @default.
• W2549071489 cites W2108722121 @default.
• W2549071489 cites W2117392174 @default.
• W2549071489 cites W2124157901 @default.
• W2549071489 cites W2127265570 @default.
• W2549071489 cites W2139308282 @default.
• W2549071489 cites W2148984136 @default.
• W2549071489 cites W2151334198 @default.
• W2549071489 cites W2153397671 @default.
• W2549071489 cites W2156678687 @default.
• W2549071489 cites W2203710366 @default.
• W2549071489 cites W2233723355 @default.
• W2549071489 cites W2262238062 @default.
• W2549071489 cites W2324454193 @default.
• W2549071489 cites W2332591352 @default.
• W2549071489 cites W2406411725 @default.
• W2549071489 cites W2487223419 @default.
• W2549071489 doi "https://doi.org/10.18632/oncotarget.13529" @default.
• W2549071489 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5349983" @default.
• W2549071489 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27888617" @default.
• W2549071489 hasPublicationYear "2016" @default.
• W2549071489 type Work @default.
• W2549071489 sameAs 2549071489 @default.
• W2549071489 citedByCount "19" @default.
• W2549071489 countsByYear W25490714892017 @default.
• W2549071489 countsByYear W25490714892018 @default.
• W2549071489 countsByYear W25490714892019 @default.
• W2549071489 countsByYear W25490714892020 @default.
• W2549071489 countsByYear W25490714892021 @default.
• W2549071489 countsByYear W25490714892022 @default.
• W2549071489 countsByYear W25490714892023 @default.
• W2549071489 crossrefType "journal-article" @default.
• W2549071489 hasAuthorship W2549071489A5000047091 @default.
• W2549071489 hasAuthorship W2549071489A5009893662 @default.
• W2549071489 hasAuthorship W2549071489A5011718542 @default.
• W2549071489 hasAuthorship W2549071489A5019878183 @default.
• W2549071489 hasAuthorship W2549071489A5058785584 @default.
• W2549071489 hasAuthorship W2549071489A5063894501 @default.
• W2549071489 hasAuthorship W2549071489A5073793918 @default.
• W2549071489 hasBestOaLocation W25490714891 @default.
• W2549071489 hasConcept C104317684 @default.
• W2549071489 hasConcept C121608353 @default.
• W2549071489 hasConcept C126322002 @default.
• W2549071489 hasConcept C127561419 @default.
• W2549071489 hasConcept C134018914 @default.
• W2549071489 hasConcept C170493617 @default.
• W2549071489 hasConcept C182704531 @default.
• W2549071489 hasConcept C185592680 @default.
• W2549071489 hasConcept C190283241 @default.
• W2549071489 hasConcept C2779399171 @default.
• W2549071489 hasConcept C2779438470 @default.
• W2549071489 hasConcept C2780804394 @default.
• W2549071489 hasConcept C31033888 @default.
• W2549071489 hasConcept C502942594 @default.
• W2549071489 hasConcept C55493867 @default.
• W2549071489 hasConcept C555283112 @default.
• W2549071489 hasConcept C71924100 @default.
• W2549071489 hasConcept C86803240 @default.
• W2549071489 hasConceptScore W2549071489C104317684 @default.
• W2549071489 hasConceptScore W2549071489C121608353 @default.
• W2549071489 hasConceptScore W2549071489C126322002 @default.
• W2549071489 hasConceptScore W2549071489C127561419 @default.

• next