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- W2549118745 abstract "BACKGROUND: The observed coexistence of COPD and cardiovascular disease (CVD) may be interrelated through inflammatory processes. Here we investigated the relationship between angiopoietin-like protein 4 (ANGPTL4), an acute phase protein, and cardiovascular function in patients with COPD. METHODS: In a cohort study we assessed serum levels of ANGPTL4, lung function (FEV 1 ), vascular status (ankle-brachial index [ABI]), cardiac function (N-terminal pro-B-Type natriuretic peptide [NT-proBNP], and traditional CVD risk factors like the components of the metabolic syndrome plus hs-CRP, physical activity, and history of coronary artery disease. Our study groups included 74 patients with COPD (GOLD stage I to IV), 12 smoking controls with chronic bronchitis and normal lung function, and 18 non-smoking controls without any lung disease. RESULTS: Levels of ANGPTL4 were increased in COPD patients compared to non-smoking controls (p=0.026). ANGPTL4 did not differ between active smokers and ex- or never-smokers (p=0.75). Using clinically established cut-off values for ABI (i.e. 0.90) and NT-pro-BNP (i.e. 125 pg/mL), we found the level of ANGPTL4 to be clearly different (p=0.010 and p CONCLUSIONS: Serum ANGPTL4 is an independent predictor of vascular and cardiac function in patients with COPD. The increased circulating levels of ANGPTL4 may reflect a pathophysiologic link between COPD and CVD." @default.
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- W2549118745 date "2016-09-01" @default.
- W2549118745 modified "2023-09-22" @default.
- W2549118745 title "Association of angiopoietin-like protein 4 with cardiovascular function in patients with COPD" @default.
- W2549118745 doi "https://doi.org/10.1183/13993003.congress-2016.oa3004" @default.
- W2549118745 hasPublicationYear "2016" @default.
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