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- W2549202323 abstract "Background: While obstructive sleep apnea (OSA) is associated with overall cardiovascular disease and mortality, the association with atherosclerotic cardiovascular disease is less clear, especially in women. Recently, OSA during REM-sleep has been suggested to have more severe adverse effects on the cardiovascular system than OSA during nonREM-sleep, but the possible association between OSA during REM sleep and signs of atherosclerosis has not been studied. Aims: The aim of this study was to examine the possible association between different measures of OSA, including OSA during REM sleep, and early signs of atherosclerosis. Methods: In the community-based cohort study “Sleep and Health in Women” (SHE) 400 women underwent a whole night polysomnography, anthropometric measurements, blood sampling, blood pressure measurement and answered a questionnaire about medical conditions. During a follow-up study ten years later 238 of the original participants, free of known atherosclerotic disease at baseline, also underwent a high-frequency ultrasound of the common carotid artery to asses the intima-media thickness (IMT) as well ass the individual thickness of the intima. Results: After adjustment for confounders there were no clear association between AHI or ODI and IMT or intimal thickness. Severe sleep apnea during REM-sleep (REM-AHI > 30) was associated with a thicker intima and this association was still significant after adjustment for age, BMI, alcohol, smoking and CPAP-treatment (b-coef 0.0089, p-value 0.009) as well as for systolic blood pressure, lipid levels and diabetes (b-coef 0.0090, p-value 0.009). Conclusion: Severe sleep apnea during REM sleep is associated with early signs of atherosclerosis." @default.
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- W2549202323 date "2016-09-01" @default.
- W2549202323 modified "2023-09-23" @default.
- W2549202323 title "Sleep apnea during REM-sleep is associated with early signs of atherosclerosis" @default.
- W2549202323 doi "https://doi.org/10.1183/13993003.congress-2016.pa2076" @default.
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