FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2549202587> ?p ?o ?g. }

• W2549202587 endingPage "117" @default.
• W2549202587 startingPage "108" @default.
• W2549202587 abstract "Sauchinone is a pharmacologically active compound isolated from Saururus chinensis, which has been used as a traditional Oriental medicine to treat fever, jaundice, and various inflammatory diseases. In this study, we investigated the effect of sauchinone against hepatocellular carcinoma (HCC) and sought to elucidate the mechanism involved. Cell viability was measured by an MTT assay. Cell cycle distributions and the mitochondrial membrane potential were analyzed using flow cytometry. Cell death was analyzed by annexin V assay, 4′,6-diamidino-2-phenylindole staining, and terminal deoxynucleotidyl transferase dUTP nick-end labeling assay. Protein and mRNA levels were assessed by western blot and real-time PCR, respectively. Malignant properties were investigated by a wound healing migration assay and invasion assay. Sauchinone suppressed the proliferation of human HCC cells in a dose-dependent manner. Moreover, it induced the G0/G1 phase cell cycle arrest and mitochondrial dysfunction and then triggered the apoptosis by activating the JNK/p38 pathway in Huh-7 cells. In addition, sauchinone induced the activation of the AMP-activated protein kinase (AMPK) pathway, and compound C (an AMPK inhibitor) blocked the sauchinone-induced mitochondrial dysfunction. The AMPK activation by sauchinone inhibited the phosphorylation of the mammalian target of rapamycin (mTOR) and its downstream targets, such as ribosomal protein S6 kinase 1 and eIF4E-binding protein 1. Furthermore, sauchinone attenuated key proangiogenic factors, including hypoxia-inducible factor-1α, vascular endothelial growth factor, and plasminogen activator inhibitor-1, resulting in decreased migration and invasion of HCC cells. These results provide evidence for sauchinone to be considered as a potent anticancer agent by targeting of the AMPK-mTOR pathway in HCC." @default.
• W2549202587 created "2016-11-30" @default.
• W2549202587 creator A5001333013 @default.
• W2549202587 creator A5030876025 @default.
• W2549202587 creator A5076132049 @default.
• W2549202587 creator A5084900880 @default.
• W2549202587 date "2017-01-01" @default.
• W2549202587 modified "2023-10-18" @default.
• W2549202587 title "Sauchinone exerts anticancer effects by targeting AMPK signaling in hepatocellular carcinoma cells" @default.
• W2549202587 cites W1495274944 @default.
• W2549202587 cites W1563676220 @default.
• W2549202587 cites W1567902550 @default.
• W2549202587 cites W181093158 @default.
• W2549202587 cites W1964120573 @default.
• W2549202587 cites W1970023517 @default.
• W2549202587 cites W1976385326 @default.
• W2549202587 cites W1991464224 @default.
• W2549202587 cites W1994928591 @default.
• W2549202587 cites W1995938892 @default.
• W2549202587 cites W1996983679 @default.
• W2549202587 cites W2001568034 @default.
• W2549202587 cites W2001775267 @default.
• W2549202587 cites W2004241472 @default.
• W2549202587 cites W2014052977 @default.
• W2549202587 cites W2025567696 @default.
• W2549202587 cites W2035625786 @default.
• W2549202587 cites W2041163647 @default.
• W2549202587 cites W2059305522 @default.
• W2549202587 cites W2062198431 @default.
• W2549202587 cites W2062412222 @default.
• W2549202587 cites W2066700651 @default.
• W2549202587 cites W2067450342 @default.
• W2549202587 cites W2072763207 @default.
• W2549202587 cites W2075426577 @default.
• W2549202587 cites W2079580613 @default.
• W2549202587 cites W2085338671 @default.
• W2549202587 cites W2095416319 @default.
• W2549202587 cites W2114825009 @default.
• W2549202587 cites W2115750021 @default.
• W2549202587 cites W2123387119 @default.
• W2549202587 cites W2123631154 @default.
• W2549202587 cites W2128188903 @default.
• W2549202587 cites W2148042269 @default.
• W2549202587 cites W2151766741 @default.
• W2549202587 cites W2157000380 @default.
• W2549202587 cites W2162242700 @default.
• W2549202587 cites W2163069245 @default.
• W2549202587 cites W2177503988 @default.
• W2549202587 cites W4232534952 @default.
• W2549202587 cites W852643881 @default.
• W2549202587 doi "https://doi.org/10.1016/j.cbi.2016.11.016" @default.
• W2549202587 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27871897" @default.
• W2549202587 hasPublicationYear "2017" @default.
• W2549202587 type Work @default.
• W2549202587 sameAs 2549202587 @default.
• W2549202587 citedByCount "32" @default.
• W2549202587 countsByYear W25492025872017 @default.
• W2549202587 countsByYear W25492025872018 @default.
• W2549202587 countsByYear W25492025872019 @default.
• W2549202587 countsByYear W25492025872020 @default.
• W2549202587 countsByYear W25492025872021 @default.
• W2549202587 countsByYear W25492025872022 @default.
• W2549202587 countsByYear W25492025872023 @default.
• W2549202587 crossrefType "journal-article" @default.
• W2549202587 hasAuthorship W2549202587A5001333013 @default.
• W2549202587 hasAuthorship W2549202587A5030876025 @default.
• W2549202587 hasAuthorship W2549202587A5076132049 @default.
• W2549202587 hasAuthorship W2549202587A5084900880 @default.
• W2549202587 hasConcept C153911025 @default.
• W2549202587 hasConcept C184235292 @default.
• W2549202587 hasConcept C185592680 @default.
• W2549202587 hasConcept C190283241 @default.
• W2549202587 hasConcept C2780124434 @default.
• W2549202587 hasConcept C2780783641 @default.
• W2549202587 hasConcept C29537977 @default.
• W2549202587 hasConcept C502942594 @default.
• W2549202587 hasConcept C53227056 @default.
• W2549202587 hasConcept C55493867 @default.
• W2549202587 hasConcept C62478195 @default.
• W2549202587 hasConcept C86554907 @default.
• W2549202587 hasConcept C86803240 @default.
• W2549202587 hasConcept C95444343 @default.
• W2549202587 hasConcept C97029542 @default.
• W2549202587 hasConceptScore W2549202587C153911025 @default.
• W2549202587 hasConceptScore W2549202587C184235292 @default.
• W2549202587 hasConceptScore W2549202587C185592680 @default.
• W2549202587 hasConceptScore W2549202587C190283241 @default.
• W2549202587 hasConceptScore W2549202587C2780124434 @default.
• W2549202587 hasConceptScore W2549202587C2780783641 @default.
• W2549202587 hasConceptScore W2549202587C29537977 @default.
• W2549202587 hasConceptScore W2549202587C502942594 @default.
• W2549202587 hasConceptScore W2549202587C53227056 @default.
• W2549202587 hasConceptScore W2549202587C55493867 @default.
• W2549202587 hasConceptScore W2549202587C62478195 @default.
• W2549202587 hasConceptScore W2549202587C86554907 @default.
• W2549202587 hasConceptScore W2549202587C86803240 @default.
• W2549202587 hasConceptScore W2549202587C95444343 @default.
• W2549202587 hasConceptScore W2549202587C97029542 @default.

• next