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- W2549203425 endingPage "515" @default.
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- W2549203425 abstract "Synchrony of biological processes with environmental cues developed over millennia to match growth, reproduction and senescence. This entails a complex interplay of genetic, metabolic, chemical, light, hormonal and hedonistic factors across life forms. Sleep is one of the most prominent rhythms where such a match is established. Over the past 100 years or so, it has been possible to disturb the synchrony between sleep-wake cycle and environmental cues. Development of electric lights, shift work and continual accessibility of the internet has disrupted this match. As a result, many non-communicable diseases such as obesity, insulin resistance, type 2 diabetes, coronary artery disease and malignancies have been attributed in part to such disruption. In this presentation a review is made of the origin and evolution of sleep studies, the pathogenic mediators for such asynchrony, clinical evidence and relevance and suggested management options to deal with the disturbances." @default.
- W2549203425 created "2016-11-30" @default.
- W2549203425 creator A5048250534 @default.
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- W2549203425 date "2016-01-01" @default.
- W2549203425 modified "2023-10-11" @default.
- W2549203425 title "Sleep, circadian dysrhythmia, obesity and diabetes" @default.
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- W2549203425 doi "https://doi.org/10.4239/wjd.v7.i19.515" @default.
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