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- W2549253974 abstract "Cathelicidins are small cationic antimicrobial peptides, whose essential roles in several distinct pathophysiological processes, including antimicrobial activity, cell proliferation and migration, immune-regulatory function, angiogenesis and wound healing, have been thoroughly scrutinized in the past two decades. In this review, several lines of new evidence are provided to show another novel function of cathelicidins, including LL-37 in humans and a mouse ortholog of LL-37, i.e., murine cathelicidin-related antimicrobial peptide (mCRAMP), in the inhibition of osteoclast formation and function. Moreover, LL-37 can function to accelerate bone regeneration in a model of rat calvarial bone defect. All of these latest findings point toward an emerging role of cathelicidins in bone biology. With the implication of cathelicidins in bone metabolism, it is hoped that the cathelicidins will be therapeutically beneficial for future clinical uses in dentistry, especially for bone regeneration in a common bone-resorbing disease like periodontitis." @default.
- W2549253974 created "2016-11-30" @default.
- W2549253974 creator A5057715371 @default.
- W2549253974 date "2014-01-01" @default.
- W2549253974 modified "2023-09-24" @default.
- W2549253974 title "An Emerging Role of Cathelicidin Antimicrobial Peptides in Bone Biology" @default.
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