Matches in SemOpenAlex for { <https://semopenalex.org/work/W2549273024> ?p ?o ?g. }
- W2549273024 endingPage "373" @default.
- W2549273024 startingPage "355" @default.
- W2549273024 abstract "We review the evidence that infectious agents, including those that become dormant within the host, have a major role to play in much of the etiology of rheumatoid arthritis and the inflammation that is its hallmark. This occurs in particular because they can produce cross-reactive (auto-)antigens, as well as potent inflammagens such as lipopolysaccharide that can themselves catalyze further inflammagenesis, including via β-amyloid formation. A series of observables coexist in many chronic, inflammatory diseases as well as rheumatoid arthritis. They include iron dysregulation, hypercoagulability, anomalous morphologies of host erythrocytes, and microparticle formation. Iron dysregulation may be responsible for the periodic regrowth and resuscitation of the dormant bacteria, with concomitant inflammagen production. The present systems biology analysis benefits from the philosophical idea of coherence, that reflects the principle that if a series of ostensibly unrelated findings are brought together into a self-consistent narrative, that narrative is thereby strengthened. As such, we provide a coherent and testable narrative for the major involvement of (often dormant) bacteria in rheumatoid arthritis." @default.
- W2549273024 created "2016-11-30" @default.
- W2549273024 creator A5005525360 @default.
- W2549273024 creator A5015696712 @default.
- W2549273024 creator A5061843707 @default.
- W2549273024 creator A5077370611 @default.
- W2549273024 date "2016-11-26" @default.
- W2549273024 modified "2023-10-14" @default.
- W2549273024 title "Major involvement of bacterial components in rheumatoid arthritis and its accompanying oxidative stress, systemic inflammation and hypercoagulability" @default.
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