Matches in SemOpenAlex for { <https://semopenalex.org/work/W2549274489> ?p ?o ?g. }
Showing items 1 to 46 of
46
with 100 items per page.
- W2549274489 abstract "Youhave doneRayWhite andmeagreat honor inselectingusfortheAllen Awardthis year, andIwantfirst ofall toexpress myappreciation ofit. Eventhough Ireceived myPh.D. fromtheHumanGenetics DepartmentattheUniversity ofMichigan, Inever imagined that Iwould contribute directly tothefield let alone receive theAllen Award. Thechairmanofthedepartment atMichigan inthose days was JimNeel, whobelieved that thediscipline ofhuman madesense only inthecontext ofthelarger discipline, genetics, thatcovered thestudy ofinheritance inallliving things. Inthis talk, Iwill tell youhowtheidea ofmaking agenetic mapbyusing restriction-frag ment polymorphisms arose outofafusion ofclassical andmolecular genetics inother model organisms. Iwill trytoshowyouthat thebasic ideas underlying RFLPmapping have adistinguished history dating backtothebeginning ofthis century. Myconclusion isthat through theadvent ofDNA-based technology thestudy ofhumangenetics, fromthepoint ofviewofexperimental practice andnotjust basic principle, hasbecome reunified withgeneral just asJimNeelalways imagined itmust. Therediscovery ofMendel inthefirst years ofthis century wasimmediately followed bytherecognition that somehumantraits, indeed somehumandiseases, areinherited according toMendel's laws. Itsoonbecameunmistakably clear thatthemechanisms of heredity inhumans areentirely typical ofthose inall higher eukaryotes. Amongtheearliest post-Mendelian discoveries wastheprinciple ofgenetic linkage andthe idea ofalinkage map(Sturtevant 1913). Yetlinkage mapping inhumans wasnotpracticed onalarge scale until after 1980, eventhough theapplicability ofthe" @default.
- W2549274489 created "2016-11-30" @default.
- W2549274489 creator A5077542898 @default.
- W2549274489 date "1990-01-01" @default.
- W2549274489 modified "2023-09-24" @default.
- W2549274489 title "1989AllenAwardAddress: TheAmerican Society ofHuman Genetics AnnualMeeting, Baltimore" @default.
- W2549274489 cites W2058707913 @default.
- W2549274489 cites W2161024497 @default.
- W2549274489 cites W2187529545 @default.
- W2549274489 hasPublicationYear "1990" @default.
- W2549274489 type Work @default.
- W2549274489 sameAs 2549274489 @default.
- W2549274489 citedByCount "0" @default.
- W2549274489 crossrefType "journal-article" @default.
- W2549274489 hasAuthorship W2549274489A5077542898 @default.
- W2549274489 hasConcept C104317684 @default.
- W2549274489 hasConcept C111919701 @default.
- W2549274489 hasConcept C138885662 @default.
- W2549274489 hasConcept C143098186 @default.
- W2549274489 hasConcept C175783326 @default.
- W2549274489 hasConcept C2779438500 @default.
- W2549274489 hasConcept C41008148 @default.
- W2549274489 hasConcept C53553401 @default.
- W2549274489 hasConcept C54355233 @default.
- W2549274489 hasConcept C78458016 @default.
- W2549274489 hasConcept C86803240 @default.
- W2549274489 hasConcept C95457728 @default.
- W2549274489 hasConceptScore W2549274489C104317684 @default.
- W2549274489 hasConceptScore W2549274489C111919701 @default.
- W2549274489 hasConceptScore W2549274489C138885662 @default.
- W2549274489 hasConceptScore W2549274489C143098186 @default.
- W2549274489 hasConceptScore W2549274489C175783326 @default.
- W2549274489 hasConceptScore W2549274489C2779438500 @default.
- W2549274489 hasConceptScore W2549274489C41008148 @default.
- W2549274489 hasConceptScore W2549274489C53553401 @default.
- W2549274489 hasConceptScore W2549274489C54355233 @default.
- W2549274489 hasConceptScore W2549274489C78458016 @default.
- W2549274489 hasConceptScore W2549274489C86803240 @default.
- W2549274489 hasConceptScore W2549274489C95457728 @default.
- W2549274489 hasLocation W25492744891 @default.
- W2549274489 hasOpenAccess W2549274489 @default.
- W2549274489 hasPrimaryLocation W25492744891 @default.
- W2549274489 isParatext "false" @default.
- W2549274489 isRetracted "false" @default.
- W2549274489 magId "2549274489" @default.
- W2549274489 workType "article" @default.