Matches in SemOpenAlex for { <https://semopenalex.org/work/W2549278898> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W2549278898 endingPage "S1" @default.
- W2549278898 startingPage "S1" @default.
- W2549278898 abstract "Pre-transplantation anti-major histocompatibility complex class-I related chain A (MICA) sensitization is an uncommon event and its role in kidney graft evolution is not completely defined. Even when kidney allografts are well matched for HLA as in living related transplant and anti-HLA antibodies are not detected, graft rejection can still occur. Anti MICA antibody is reportedly associated with poor transplant outcomes and a high risk of acute and chronic rejection in renal transplantation. A retrospective study of patients undergone living renal transplantation between years 2000-2014 was performed. Recipients were classified in two groups, pre-transplantation Anti MICA antibody positive group (n=17) and antibody negative comparison group (n=17). Patients with anti HLA antibodies were excluded and only isolated MICA positive patients were included in the study group. Both groups were comparable in recipient age, donor age, donor relation, HLA and immunosuppression. Patients with pre transplant MICA antibody positivity were associated with increased acute rejection rate as compared to comparison group (47% vs 11.7 %, p value= 0.02). Renal function in MICA positive group and comparison group were comparable over a mean follow up of 6.5 years (mean creatinine 1.58 vs 1.53 mg/dl). Rate of chronic rejection was same in both groups (5.8%). No patient loss or graft loss occurred in either group over mean follow up of 6.5 years. Isolated Anti MICA antibody positivity is uncommon event. Pre transplant anti MICA antibody positivity is associated with increased acute rejection rates. However chronic rejection rates and renal function are comparable in both groups. Thus our study emphasizes that MICA antibody positive patients may require more aggressive immunosuppression. Role of desensitization has to be defined." @default.
- W2549278898 created "2016-11-30" @default.
- W2549278898 creator A5011173163 @default.
- W2549278898 creator A5036270268 @default.
- W2549278898 creator A5063008501 @default.
- W2549278898 creator A5080472677 @default.
- W2549278898 date "2016-11-01" @default.
- W2549278898 modified "2023-09-26" @default.
- W2549278898 title "P01 ANTI MICA (MAJOR HISTOCOMPATIBILITY COMPLEX CLASS I RELATED CHAIN A) ANTIBODY, WHETHER TO TREAT OR AVOID IN RENAL TRANSPLANTATION?" @default.
- W2549278898 doi "https://doi.org/10.1016/j.ekir.2016.09.007" @default.
- W2549278898 hasPublicationYear "2016" @default.
- W2549278898 type Work @default.
- W2549278898 sameAs 2549278898 @default.
- W2549278898 citedByCount "0" @default.
- W2549278898 crossrefType "journal-article" @default.
- W2549278898 hasAuthorship W2549278898A5011173163 @default.
- W2549278898 hasAuthorship W2549278898A5036270268 @default.
- W2549278898 hasAuthorship W2549278898A5063008501 @default.
- W2549278898 hasAuthorship W2549278898A5080472677 @default.
- W2549278898 hasBestOaLocation W25492788981 @default.
- W2549278898 hasConcept C126322002 @default.
- W2549278898 hasConcept C147483822 @default.
- W2549278898 hasConcept C159641895 @default.
- W2549278898 hasConcept C159654299 @default.
- W2549278898 hasConcept C188280979 @default.
- W2549278898 hasConcept C202965653 @default.
- W2549278898 hasConcept C203014093 @default.
- W2549278898 hasConcept C2780252810 @default.
- W2549278898 hasConcept C2780303639 @default.
- W2549278898 hasConcept C2780306776 @default.
- W2549278898 hasConcept C2911091166 @default.
- W2549278898 hasConcept C71924100 @default.
- W2549278898 hasConcept C90924648 @default.
- W2549278898 hasConceptScore W2549278898C126322002 @default.
- W2549278898 hasConceptScore W2549278898C147483822 @default.
- W2549278898 hasConceptScore W2549278898C159641895 @default.
- W2549278898 hasConceptScore W2549278898C159654299 @default.
- W2549278898 hasConceptScore W2549278898C188280979 @default.
- W2549278898 hasConceptScore W2549278898C202965653 @default.
- W2549278898 hasConceptScore W2549278898C203014093 @default.
- W2549278898 hasConceptScore W2549278898C2780252810 @default.
- W2549278898 hasConceptScore W2549278898C2780303639 @default.
- W2549278898 hasConceptScore W2549278898C2780306776 @default.
- W2549278898 hasConceptScore W2549278898C2911091166 @default.
- W2549278898 hasConceptScore W2549278898C71924100 @default.
- W2549278898 hasConceptScore W2549278898C90924648 @default.
- W2549278898 hasIssue "4" @default.
- W2549278898 hasLocation W25492788981 @default.
- W2549278898 hasLocation W25492788982 @default.
- W2549278898 hasOpenAccess W2549278898 @default.
- W2549278898 hasPrimaryLocation W25492788981 @default.
- W2549278898 hasRelatedWork W1486584413 @default.
- W2549278898 hasRelatedWork W1511302864 @default.
- W2549278898 hasRelatedWork W2027826350 @default.
- W2549278898 hasRelatedWork W2040879941 @default.
- W2549278898 hasRelatedWork W2052365623 @default.
- W2549278898 hasRelatedWork W2077996663 @default.
- W2549278898 hasRelatedWork W2087086071 @default.
- W2549278898 hasRelatedWork W2392082400 @default.
- W2549278898 hasRelatedWork W3031585746 @default.
- W2549278898 hasRelatedWork W3136218469 @default.
- W2549278898 hasVolume "1" @default.
- W2549278898 isParatext "false" @default.
- W2549278898 isRetracted "false" @default.
- W2549278898 magId "2549278898" @default.
- W2549278898 workType "article" @default.