FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2549322435> ?p ?o ?g. }

• W2549322435 endingPage "79" @default.
• W2549322435 startingPage "79" @default.
• W2549322435 abstract "<p><strong>Objective: </strong>The current work was attempted to formulate and evaluate a controlled-release matrix-type ocular inserts containing a combination of brimonidine tartrate and timolol maleate, with a view to sustain the drug release in the cul-de-sac of the eye.<strong></strong></p><p><strong>Methods: </strong>Initially, the infrared studies were done to determine the drug–polymer interactions. Sodium alginate-loaded ocuserts were prepared by solvent casting technique. Varying the concentrations of polymer—sodium alginate, plasticizer—glycerine, and cross-linking agent—calcium chloride by keeping the drug concentration constant, made a total of nine formulations. These formulations were evaluated for its appearance, drug content, weight uniformity, thickness uniformity, percentage moisture loss, percentage moisture absorption, and <em>in vitro </em>release profile of the ocuserts. Finally, accelerated stability studies and the release kinetics were performed on the optimised formulation.<strong></strong></p><p><strong>Results: </strong>It was perceived that polymer, plasticizer, and calcium chloride had a significant influence on the drug release. The data obtained from the formulations showed that formulation—F9 was the optimised formulation, which exhibited better drug release. The release data of the optimised formulation tested on the kinetic models revealed that it exhibited first-order release kinetics. <strong></strong></p><p><strong>Conclusion: </strong>It can be concluded that a natural bioadhesive hydrophilic polymer such as sodium alginate can be used as a film former to load water soluble and hydrophilic drugs like brimonidine tartrate and timolol maleate. Among all formulations, F9 with 400 mg sodium alginate, 2% calcium chloride and 60 mg glycerin were found to be the most suitable insert in terms of appearance, ease of handling, thickness, <em>in vitro</em> drug release and stability.</p>" @default.
• W2549322435 created "2016-11-30" @default.
• W2549322435 creator A5056322131 @default.
• W2549322435 creator A5062256056 @default.
• W2549322435 date "2016-12-31" @default.
• W2549322435 modified "2023-09-26" @default.
• W2549322435 title "DESIGN AND EVALUATION OF CONTROLLED-RELEASE OCULAR INSERTS OF BRIMONIDINE-TARTRATE AND TIMOLOL MALEATE" @default.
• W2549322435 cites W1508262201 @default.
• W2549322435 cites W1984458301 @default.
• W2549322435 cites W2022696506 @default.
• W2549322435 cites W2087041915 @default.
• W2549322435 cites W2089650197 @default.
• W2549322435 cites W2099896311 @default.
• W2549322435 cites W2116566868 @default.
• W2549322435 cites W2126691225 @default.
• W2549322435 cites W2165919137 @default.
• W2549322435 cites W2185249160 @default.
• W2549322435 cites W2189097057 @default.
• W2549322435 cites W2245225435 @default.
• W2549322435 cites W2325856553 @default.
• W2549322435 cites W2098031487 @default.
• W2549322435 cites W2184902536 @default.
• W2549322435 cites W2188422030 @default.
• W2549322435 doi "https://doi.org/10.22159/ijpps.2017v9i1.15199" @default.
• W2549322435 hasPublicationYear "2016" @default.
• W2549322435 type Work @default.
• W2549322435 sameAs 2549322435 @default.
• W2549322435 citedByCount "2" @default.
• W2549322435 countsByYear W25493224352019 @default.
• W2549322435 countsByYear W25493224352020 @default.
• W2549322435 crossrefType "journal-article" @default.
• W2549322435 hasAuthorship W2549322435A5056322131 @default.
• W2549322435 hasAuthorship W2549322435A5062256056 @default.
• W2549322435 hasBestOaLocation W25493224351 @default.
• W2549322435 hasConcept C13965031 @default.
• W2549322435 hasConcept C141071460 @default.
• W2549322435 hasConcept C178790620 @default.
• W2549322435 hasConcept C185592680 @default.
• W2549322435 hasConcept C2776727336 @default.
• W2549322435 hasConcept C2778073030 @default.
• W2549322435 hasConcept C2781092963 @default.
• W2549322435 hasConcept C43617362 @default.
• W2549322435 hasConcept C537181965 @default.
• W2549322435 hasConcept C58968531 @default.
• W2549322435 hasConcept C71924100 @default.
• W2549322435 hasConceptScore W2549322435C13965031 @default.
• W2549322435 hasConceptScore W2549322435C141071460 @default.
• W2549322435 hasConceptScore W2549322435C178790620 @default.
• W2549322435 hasConceptScore W2549322435C185592680 @default.
• W2549322435 hasConceptScore W2549322435C2776727336 @default.
• W2549322435 hasConceptScore W2549322435C2778073030 @default.
• W2549322435 hasConceptScore W2549322435C2781092963 @default.
• W2549322435 hasConceptScore W2549322435C43617362 @default.
• W2549322435 hasConceptScore W2549322435C537181965 @default.
• W2549322435 hasConceptScore W2549322435C58968531 @default.
• W2549322435 hasConceptScore W2549322435C71924100 @default.
• W2549322435 hasIssue "1" @default.
• W2549322435 hasLocation W25493224351 @default.
• W2549322435 hasOpenAccess W2549322435 @default.
• W2549322435 hasPrimaryLocation W25493224351 @default.
• W2549322435 hasRelatedWork W1967566161 @default.
• W2549322435 hasRelatedWork W2004701608 @default.
• W2549322435 hasRelatedWork W2018949056 @default.
• W2549322435 hasRelatedWork W2062116536 @default.
• W2549322435 hasRelatedWork W2065005955 @default.
• W2549322435 hasRelatedWork W2086728261 @default.
• W2549322435 hasRelatedWork W2097616776 @default.
• W2549322435 hasRelatedWork W2159037528 @default.
• W2549322435 hasRelatedWork W2549322435 @default.
• W2549322435 hasRelatedWork W2727260890 @default.
• W2549322435 hasVolume "9" @default.
• W2549322435 isParatext "false" @default.
• W2549322435 isRetracted "false" @default.
• W2549322435 magId "2549322435" @default.
• W2549322435 workType "article" @default.