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- W2549408054 abstract "Introduction: Collagen type VII (col7) is the main component of the anchoring fibrils that connects the basement membrane to the underlying interstitial matrix and has mainly been investigated for its role in blistering skin diseases. We wanted to elucidate if the remodeling of col7 was associated with pulmonary diseases and thus developed an assay assessing col7 degradation in serum and evaluated it in patients with COPD and systemic sclerosis (SSC). Methods: We identified a specific fragment of col7 in serum from COPD patients, which was not found in controls, using mass spectrometry. A monoclonal antibody was raised against the first ten amino acids of the neo-epitope and employed in a competitive ELISA (C7). The C7 assay was validated technically and was subsequently evaluated in patients with COPD (n=68) and early (n=20) and late (n=20) diffuse SSC. Results: We developed a technically robust competitive ELISA that was highly specific for a col7 fragment named C7. The assay showed acceptable inter- and intra-assay variation, linearity, analyte stability, and interference. Patients with COPD had significantly higher serum C7 levels as compared with healthy controls (p Conclusions: Serological levels of a specific col7 fragment may be assessed by the newly developed C7 assay. Col7 remodeling was associated with COPD and SSC, indicating that C7 may be used in the assessment of these diseases. Furthermore, C7 may be a marker of disease activity as only early SSC patients, who have faster progression rates, showed significantly elevated serum levels." @default.
- W2549408054 created "2016-11-30" @default.
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- W2549408054 date "2016-09-01" @default.
- W2549408054 modified "2023-09-27" @default.
- W2549408054 title "A neo-epitope of collagen type VII (C7) is elevated in serum of patients with COPD and SSC" @default.
- W2549408054 doi "https://doi.org/10.1183/13993003.congress-2016.pa3436" @default.
- W2549408054 hasPublicationYear "2016" @default.
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