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- W2549457029 abstract "ACVR2 is a member of the transforming growth factor beta (TGF-β) receptor family. It is a 70-75kDa protein consisting of 513 amino acids. It is a transmembrane receptor for activin, with a cysteine-rich extracellular ligand-binding domain, a single pass transmembrane domain, and an intracellular domain with constitutive serine/threonine kinase activity. Upon binding activin, ACVR2 associates with and phosphorylates ACVR1. ACVR1, in turn, phosphorylates Smad2 and/or Smad3. Phosphorylated Smad2 and Smad3 associate with Smad4, translocate to the nucleus, and regulate gene expression. There may be other non-Smad pathways in activin signal transduction. These include the RhoA-ROCKMEKK1-JNK and MEKK1-p38 pathways. In addition to activin, other ligands such as myostatin, nodal, and bone morphogenetic protein 7 (BMP-7) may also bind to ACVR2 and affect signal transduction." @default.
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- W2549457029 date "2012-01-01" @default.
- W2549457029 modified "2023-09-27" @default.
- W2549457029 title "ACVR2A (activin A receptor, type IIA)" @default.
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