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- W2549532450 abstract "Introduction: The mechanism of bronchodilator nonresponsiveness to corticosteroids in COPD is unclear; the levels of histone deacytylase (HDAC) and oxidative stress have been implicated (New Engl J Med, 2005;352:1967). Phosphodiesterase (PDE4) inhibition of glucocorticoid resistance in human alveolar macrophages has also been shown to reverse corticosteroid resistance (Clin Exp Allergy. 2011;41:535) Aims and objectives: We therefore studied the effects of theophylline which is believed to increase HDAC levels, as well as roflumilast, a PDE inhibitor, on steroid responsiveness in COPD. Methods: Eight COPD patients (4 Males, Mean age 67.4±8.2yrs) with spirometrically documented nonresponsiveness to bronchodilators received treatment with oral theophylline for one week, followed by the addition of oral roflumilast 500 µg daily for a further one week. At the end of the first week, after baseline spirometry before and after inhaled albuterol, subjects received 40 mg oral prednisone and spirometry was repeated before and after inhaled albuterol. The studies were repeated at the end of the second week. Results: HDAC2 activity in circulating mononuclear WBCs did not change significantly from baseline at weeks 1 and 2 (baseline 2.96±0.73; week 1: 2.58±0.91; week 2: 2.81±0.40 µM/µg protein; p>0.05). Similarly there were no differences in baseline spirometric values at baseline, week 1 and week 2. Baseline Week 1 Week 2 Bronchodilator: Pre Post p Pre Post p Pre Post FVC, L 2.72 2.86 ns 2.72 2.80 ns 2.81 2.98 FEV1, L 1.18 1.33" @default.
- W2549532450 created "2016-11-30" @default.
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- W2549532450 date "2016-09-01" @default.
- W2549532450 modified "2023-09-27" @default.
- W2549532450 title "LATE-BREAKING ABSTRACT: Corticosteroid responsiveness in COPD" @default.
- W2549532450 doi "https://doi.org/10.1183/13993003.congress-2016.oa4836" @default.
- W2549532450 hasPublicationYear "2016" @default.
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