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- W2549537624 abstract "Although stenting is a useful modality to deal with tracheal stenosis, there are no definite guidelines about the timing of stent removal. Previous studies have recommended that stents should be placed for 6–18 months in cases of benign airway stenosis. However, stent-related complications such as migration and granulation tissue formation were uncommon. Topical application of mitomycin C (MMC), a strong inhibitor of fibroblast proliferation, could be a promising adjuvant therapeutic modality. We attempted to evaluate the combined use of topical MMC application and silicon stent insertion could shorten the duration of stent placement in patients with post-intubation tracheal stenosis. Seventy-eight and fifty-five year old women were referred to our center because of progressive dyspnea after short-term tracheal intubation. The forced expiratory volume in 1 second (FEV1) were 1.26 (70%) and 2.02 liters (67% of predicted), respectively. Bronchoscopy revealed more than 3.5 and 2.5 cm length strictures involving upper trachea and subglottic area. After debridement and mechanical dilatation, MMC (0.4 mg/mL) was applied circumferentially over the area of stenosis, and silicon stents (12 mm outer diameter, 3.5 and 4.5 cm length) were inserted. Stents were removed after 3 months, and their tracheae were patent without stenosis. The FEV1 increased to 1.50 (83%) and 2.38 liters (91% of predicted) in a month after stent removal, respectively. Both of them have remained stable without recurrence of symptoms. The combined use of topical mitomycin C application and stent insertion may shorten the duration of stent placement in patients with benign tracheal stenosis." @default.
- W2549537624 created "2016-11-30" @default.
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- W2549537624 date "2016-09-01" @default.
- W2549537624 modified "2023-09-27" @default.
- W2549537624 title "An attempt to remove tracheal stents earlier: The combined use of topical mitomycin C and silicon stent insertion" @default.
- W2549537624 doi "https://doi.org/10.1183/13993003.congress-2016.pa3835" @default.
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