Matches in SemOpenAlex for { <https://semopenalex.org/work/W2549584294> ?p ?o ?g. }
- W2549584294 abstract "Exosomes are vesicles secreted to the extracellular environment through fusion with the plasma membrane of specific endosomes called multivesicular bodies (MVB) and mediate cell-to-cell communication in many biological processes. Posttranslational modifications are involved in the sorting of specific proteins into exosomes. Here we identify ISGylation as a ubiquitin-like modification that controls exosome release. ISGylation induction decreases MVB numbers and impairs exosome secretion. Using ISG15-knockout mice and mice expressing the enzymatically inactive form of the de-ISGylase USP18, we demonstrate in vitro and in vivo that ISG15 conjugation regulates exosome secretion. ISG15 conjugation triggers MVB co-localization with lysosomes and promotes the aggregation and degradation of MVB proteins. Accordingly, inhibition of lysosomal function or autophagy restores exosome secretion. Specifically, ISGylation of the MVB protein TSG101 induces its aggregation and degradation, being sufficient to impair exosome secretion. These results identify ISGylation as a novel ubiquitin-like modifier in the control of exosome production." @default.
- W2549584294 created "2016-11-30" @default.
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- W2549584294 date "2016-11-24" @default.
- W2549584294 modified "2023-10-14" @default.
- W2549584294 title "ISGylation controls exosome secretion by promoting lysosomal degradation of MVB proteins" @default.
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- W2549584294 cites W1606338704 @default.
- W2549584294 cites W1967391569 @default.
- W2549584294 cites W1973572007 @default.
- W2549584294 cites W1975423316 @default.
- W2549584294 cites W1976290862 @default.
- W2549584294 cites W1982606786 @default.
- W2549584294 cites W1985175917 @default.
- W2549584294 cites W1985844219 @default.
- W2549584294 cites W1989274589 @default.
- W2549584294 cites W1990783239 @default.
- W2549584294 cites W1993140699 @default.
- W2549584294 cites W1998079639 @default.
- W2549584294 cites W1998307755 @default.
- W2549584294 cites W2002466777 @default.
- W2549584294 cites W2004759810 @default.
- W2549584294 cites W2005154332 @default.
- W2549584294 cites W2014346055 @default.
- W2549584294 cites W2014438596 @default.
- W2549584294 cites W2015415445 @default.
- W2549584294 cites W2018576492 @default.
- W2549584294 cites W2020432242 @default.
- W2549584294 cites W2024380558 @default.
- W2549584294 cites W2033295839 @default.
- W2549584294 cites W2034662297 @default.
- W2549584294 cites W2037151930 @default.
- W2549584294 cites W2041088807 @default.
- W2549584294 cites W2041302454 @default.
- W2549584294 cites W2050745715 @default.
- W2549584294 cites W2075214367 @default.
- W2549584294 cites W2077592014 @default.
- W2549584294 cites W2081124475 @default.
- W2549584294 cites W2081345296 @default.
- W2549584294 cites W2081924373 @default.
- W2549584294 cites W2086612059 @default.
- W2549584294 cites W2086876304 @default.
- W2549584294 cites W2090675521 @default.
- W2549584294 cites W2090926836 @default.
- W2549584294 cites W2094601732 @default.
- W2549584294 cites W2095965043 @default.
- W2549584294 cites W2097512050 @default.
- W2549584294 cites W2099491642 @default.
- W2549584294 cites W2101443697 @default.
- W2549584294 cites W2103433909 @default.
- W2549584294 cites W2105306638 @default.
- W2549584294 cites W2108175824 @default.
- W2549584294 cites W2119764013 @default.
- W2549584294 cites W2123832957 @default.
- W2549584294 cites W2124644922 @default.
- W2549584294 cites W2125812410 @default.
- W2549584294 cites W2126210405 @default.
- W2549584294 cites W2130273382 @default.
- W2549584294 cites W2134635469 @default.
- W2549584294 cites W2134980069 @default.
- W2549584294 cites W2142044474 @default.
- W2549584294 cites W2142598717 @default.
- W2549584294 cites W2143618144 @default.
- W2549584294 cites W2143729276 @default.
- W2549584294 cites W2146304525 @default.
- W2549584294 cites W2151447241 @default.
- W2549584294 cites W2152021080 @default.
- W2549584294 cites W2162759745 @default.
- W2549584294 cites W2168143397 @default.
- W2549584294 cites W2169491358 @default.
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- W2549584294 doi "https://doi.org/10.1038/ncomms13588" @default.
- W2549584294 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5123068" @default.
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