Matches in SemOpenAlex for { <https://semopenalex.org/work/W2549585551> ?p ?o ?g. }
- W2549585551 endingPage "40" @default.
- W2549585551 startingPage "33" @default.
- W2549585551 abstract "Aging constitutes the central risk factor for major diseases including many forms of cancer, neurodegeneration, and cardiovascular diseases. The aging process is characterized by both global and tissue-specific changes in gene expression across taxonomically diverse species. While aging has historically been thought to entail cell-autonomous, even stochastic changes, recent evidence suggests that modulation of this process can be hierarchal, wherein manipulations of nutrient-sensing neurons (e.g., in the hypothalamus) produce peripheral effects that may modulate the aging process itself. The most robust intervention extending lifespan, plausibly impinging on the aging process, involves different modalities of dietary restriction (DR). Lifespan extension by DR is associated with broad protection against diseases (natural and engineered). Here we review potential epigenetic processes that may link lifespan to age-related diseases, particularly in the context of DR and (other) ketogenic diets, focusing on brain and hypothalamic mechanisms." @default.
- W2549585551 created "2016-11-30" @default.
- W2549585551 creator A5024455668 @default.
- W2549585551 creator A5047092890 @default.
- W2549585551 date "2017-11-01" @default.
- W2549585551 modified "2023-10-14" @default.
- W2549585551 title "Epigenetic mechanisms underlying lifespan and age-related effects of dietary restriction and the ketogenic diet" @default.
- W2549585551 cites W1506428037 @default.
- W2549585551 cites W1508556872 @default.
- W2549585551 cites W1583148430 @default.
- W2549585551 cites W1665938856 @default.
- W2549585551 cites W1764198257 @default.
- W2549585551 cites W1883566698 @default.
- W2549585551 cites W1925793145 @default.
- W2549585551 cites W1963551704 @default.
- W2549585551 cites W1963789736 @default.
- W2549585551 cites W1970112647 @default.
- W2549585551 cites W1970277428 @default.
- W2549585551 cites W1977244638 @default.
- W2549585551 cites W1982602899 @default.
- W2549585551 cites W1982903836 @default.
- W2549585551 cites W1985308585 @default.
- W2549585551 cites W1986065867 @default.
- W2549585551 cites W1987321036 @default.
- W2549585551 cites W1990710510 @default.
- W2549585551 cites W1993571663 @default.
- W2549585551 cites W1994540097 @default.
- W2549585551 cites W1995217137 @default.
- W2549585551 cites W1997145913 @default.
- W2549585551 cites W1997788251 @default.
- W2549585551 cites W1997887740 @default.
- W2549585551 cites W1999766340 @default.
- W2549585551 cites W2003363961 @default.
- W2549585551 cites W2004923406 @default.
- W2549585551 cites W2004988279 @default.
- W2549585551 cites W2007887780 @default.
- W2549585551 cites W2013451725 @default.
- W2549585551 cites W2017117976 @default.
- W2549585551 cites W2020415271 @default.
- W2549585551 cites W2021128415 @default.
- W2549585551 cites W2021264577 @default.
- W2549585551 cites W2022267544 @default.
- W2549585551 cites W2028649540 @default.
- W2549585551 cites W2029398635 @default.
- W2549585551 cites W2036265947 @default.
- W2549585551 cites W2036566832 @default.
- W2549585551 cites W2041945197 @default.
- W2549585551 cites W2042716686 @default.
- W2549585551 cites W2043485308 @default.
- W2549585551 cites W2044758458 @default.
- W2549585551 cites W2045742234 @default.
- W2549585551 cites W2046244011 @default.
- W2549585551 cites W2046459630 @default.
- W2549585551 cites W2047041417 @default.
- W2549585551 cites W2047330128 @default.
- W2549585551 cites W2050502129 @default.
- W2549585551 cites W2051098160 @default.
- W2549585551 cites W2051509673 @default.
- W2549585551 cites W2051658606 @default.
- W2549585551 cites W2052011655 @default.
- W2549585551 cites W2053184644 @default.
- W2549585551 cites W2053352181 @default.
- W2549585551 cites W2056453168 @default.
- W2549585551 cites W2062920844 @default.
- W2549585551 cites W2063226520 @default.
- W2549585551 cites W2064160537 @default.
- W2549585551 cites W2066186764 @default.
- W2549585551 cites W2066430702 @default.
- W2549585551 cites W2066762257 @default.
- W2549585551 cites W2068111215 @default.
- W2549585551 cites W2069984149 @default.
- W2549585551 cites W2071068165 @default.
- W2549585551 cites W2073151196 @default.
- W2549585551 cites W2077033935 @default.
- W2549585551 cites W2078003979 @default.
- W2549585551 cites W2081550219 @default.
- W2549585551 cites W2083134947 @default.
- W2549585551 cites W2089156556 @default.
- W2549585551 cites W2090054406 @default.
- W2549585551 cites W2090760765 @default.
- W2549585551 cites W2093934162 @default.
- W2549585551 cites W2096083625 @default.
- W2549585551 cites W2096965531 @default.
- W2549585551 cites W2097265055 @default.
- W2549585551 cites W2097948853 @default.
- W2549585551 cites W2098009444 @default.
- W2549585551 cites W2101209169 @default.
- W2549585551 cites W2101580126 @default.
- W2549585551 cites W2102872810 @default.
- W2549585551 cites W2103238221 @default.
- W2549585551 cites W2104438296 @default.
- W2549585551 cites W2104655808 @default.
- W2549585551 cites W2104868442 @default.
- W2549585551 cites W2109188407 @default.
- W2549585551 cites W2109516616 @default.
- W2549585551 cites W2109560454 @default.
- W2549585551 cites W2112365416 @default.
- W2549585551 cites W2116449899 @default.