Matches in SemOpenAlex for { <https://semopenalex.org/work/W2549623340> ?p ?o ?g. }
- W2549623340 endingPage "24" @default.
- W2549623340 startingPage "12" @default.
- W2549623340 abstract "Glycans on HIV-1 Envelope serve multiple functions including blocking epitopes from antibodies. We show that removal of glycan 301, a major target of anti-V3/glycan antibodies, has substantially different effects in two viruses. While glycan 301 on Du156.12 blocks epitopes commonly recognized by sera from chronically HIV-1-infected individuals, it does not do so on CAP45.G3, suggesting that removing the 301 glycan has a smaller effect on the integrity of the glycan shield in CAP45.G3. Changes in sensitivity to broadly neutralizing monoclonal antibodies suggest that the interaction between glycan 301 and the CD4 binding site differ substantially between these 2 viruses. Molecular modeling suggests that removal of glycan 301 likely exposes a greater surface area of the V3 and C4 regions in Du156.12. Our data indicate that the contribution of the 301 glycan to resistance to common neutralizing antibodies varies between viruses, allowing for easier selection for its loss in some viruses." @default.
- W2549623340 created "2016-11-30" @default.
- W2549623340 creator A5011012168 @default.
- W2549623340 creator A5020128637 @default.
- W2549623340 creator A5030822254 @default.
- W2549623340 creator A5050411365 @default.
- W2549623340 creator A5057150850 @default.
- W2549623340 creator A5069058583 @default.
- W2549623340 creator A5078825398 @default.
- W2549623340 creator A5082447829 @default.
- W2549623340 date "2017-01-01" @default.
- W2549623340 modified "2023-09-26" @default.
- W2549623340 title "Chinks in the armor of the HIV-1 Envelope glycan shield: Implications for immune escape from anti-glycan broadly neutralizing antibodies" @default.
- W2549623340 cites W150399887 @default.
- W2549623340 cites W1533750546 @default.
- W2549623340 cites W1555431980 @default.
- W2549623340 cites W1602599521 @default.
- W2549623340 cites W1628484047 @default.
- W2549623340 cites W1972341594 @default.
- W2549623340 cites W1974431423 @default.
- W2549623340 cites W1974716123 @default.
- W2549623340 cites W1985187896 @default.
- W2549623340 cites W1985711808 @default.
- W2549623340 cites W1987510779 @default.
- W2549623340 cites W1989174077 @default.
- W2549623340 cites W1992529182 @default.
- W2549623340 cites W1992566288 @default.
- W2549623340 cites W1993052631 @default.
- W2549623340 cites W1997677784 @default.
- W2549623340 cites W1998683102 @default.
- W2549623340 cites W2000475809 @default.
- W2549623340 cites W2000885937 @default.
- W2549623340 cites W2005061720 @default.
- W2549623340 cites W2010521915 @default.
- W2549623340 cites W2019577213 @default.
- W2549623340 cites W2020596573 @default.
- W2549623340 cites W2023273943 @default.
- W2549623340 cites W2025757334 @default.
- W2549623340 cites W2029102196 @default.
- W2549623340 cites W2032682068 @default.
- W2549623340 cites W2036018115 @default.
- W2549623340 cites W2039881406 @default.
- W2549623340 cites W2040235378 @default.
- W2549623340 cites W2046863461 @default.
- W2549623340 cites W2048787904 @default.
- W2549623340 cites W2049122170 @default.
- W2549623340 cites W2053127269 @default.
- W2549623340 cites W2056710036 @default.
- W2549623340 cites W2058632331 @default.
- W2549623340 cites W2060507246 @default.
- W2549623340 cites W2061962974 @default.
- W2549623340 cites W2065283382 @default.
- W2549623340 cites W2070086938 @default.
- W2549623340 cites W2071783872 @default.
- W2549623340 cites W2074179519 @default.
- W2549623340 cites W2075775510 @default.
- W2549623340 cites W2077977162 @default.
- W2549623340 cites W2083627780 @default.
- W2549623340 cites W2083726777 @default.
- W2549623340 cites W2095706923 @default.
- W2549623340 cites W2098781795 @default.
- W2549623340 cites W2098943363 @default.
- W2549623340 cites W2099308199 @default.
- W2549623340 cites W2107017911 @default.
- W2549623340 cites W2110499527 @default.
- W2549623340 cites W2112310185 @default.
- W2549623340 cites W2113236498 @default.
- W2549623340 cites W2122210861 @default.
- W2549623340 cites W2123360865 @default.
- W2549623340 cites W2123660365 @default.
- W2549623340 cites W2124935744 @default.
- W2549623340 cites W2128579789 @default.
- W2549623340 cites W2131034616 @default.
- W2549623340 cites W2131903471 @default.
- W2549623340 cites W2133233128 @default.
- W2549623340 cites W2134123088 @default.
- W2549623340 cites W2135151522 @default.
- W2549623340 cites W2143585030 @default.
- W2549623340 cites W2145139097 @default.
- W2549623340 cites W2145462968 @default.
- W2549623340 cites W2145909184 @default.
- W2549623340 cites W2149132834 @default.
- W2549623340 cites W2152440860 @default.
- W2549623340 cites W2159665548 @default.
- W2549623340 cites W2163558461 @default.
- W2549623340 cites W2165236706 @default.
- W2549623340 cites W2165692875 @default.
- W2549623340 cites W2168949591 @default.
- W2549623340 cites W2170978444 @default.
- W2549623340 cites W2213653348 @default.
- W2549623340 cites W2221595921 @default.
- W2549623340 cites W2259177282 @default.
- W2549623340 cites W2277500758 @default.
- W2549623340 cites W2294568087 @default.
- W2549623340 cites W2294858472 @default.
- W2549623340 cites W2294997006 @default.
- W2549623340 cites W2336507460 @default.
- W2549623340 cites W2511617912 @default.