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- W2549628327 startingPage "108" @default.
- W2549628327 abstract "Tumor targeting by nanomedicine-based therapeutics has emerged as a promising approach to overcome the lack of specificity of conventional chemotherapeutic agents and to provide clinicians the ability to overcome shortcomings of current cancer treatment. The major underlying mechanism of the design of nanomedicines was the Enhanced Permeability and Retention (EPR) effect, considered as the “royal gate” in the drug delivery field. However, after the publication of thousands of research papers, the verdict has been handed down: the EPR effect works in rodents but not in humans! Thus the basic rationale of the design and development of nanomedicines in cancer therapy is failing making it necessary to stop claiming efficacy gains via the EPR effect, while tumor targeting cannot be proved in the clinic. It is probably time to dethrone the EPR effect and to ask the question: what is the future of nanomedicines without the EPR effect? The aim of this review is to provide a general overview on (i) the current state of the EPR effect, (ii) the future of nanomedicine and (iii) the strategies of modulation of the tumor microenvironment to improve the delivery of nanomedicine." @default.
- W2549628327 created "2016-11-30" @default.
- W2549628327 creator A5064530936 @default.
- W2549628327 date "2016-12-01" @default.
- W2549628327 modified "2023-10-12" @default.
- W2549628327 title "To exploit the tumor microenvironment: Since the EPR effect fails in the clinic, what is the future of nanomedicine?" @default.
- W2549628327 cites W171233943 @default.
- W2549628327 cites W1821406191 @default.
- W2549628327 cites W1928083400 @default.
- W2549628327 cites W1937121752 @default.
- W2549628327 cites W1960327677 @default.
- W2549628327 cites W1967389270 @default.
- W2549628327 cites W1967637067 @default.
- W2549628327 cites W1967838912 @default.
- W2549628327 cites W1968029051 @default.
- W2549628327 cites W1968096010 @default.
- W2549628327 cites W1968583232 @default.
- W2549628327 cites W1968762000 @default.
- W2549628327 cites W1975088956 @default.
- W2549628327 cites W1976041621 @default.
- W2549628327 cites W1977887541 @default.
- W2549628327 cites W1979157744 @default.
- W2549628327 cites W1981870697 @default.
- W2549628327 cites W1984447304 @default.
- W2549628327 cites W1985957186 @default.
- W2549628327 cites W1989228654 @default.
- W2549628327 cites W1989230986 @default.
- W2549628327 cites W1995340305 @default.
- W2549628327 cites W2001499176 @default.
- W2549628327 cites W2002516695 @default.
- W2549628327 cites W2003338204 @default.
- W2549628327 cites W2006202974 @default.
- W2549628327 cites W2007747310 @default.
- W2549628327 cites W2015959969 @default.
- W2549628327 cites W2016834188 @default.
- W2549628327 cites W2024787650 @default.
- W2549628327 cites W2025202928 @default.
- W2549628327 cites W2025344276 @default.
- W2549628327 cites W2027292955 @default.
- W2549628327 cites W2028156849 @default.
- W2549628327 cites W2035342960 @default.
- W2549628327 cites W2035374674 @default.
- W2549628327 cites W2038449477 @default.
- W2549628327 cites W2040670989 @default.
- W2549628327 cites W2044131175 @default.
- W2549628327 cites W2046890107 @default.
- W2549628327 cites W2052580681 @default.
- W2549628327 cites W2054393872 @default.
- W2549628327 cites W2054567871 @default.
- W2549628327 cites W2055631278 @default.
- W2549628327 cites W2061593819 @default.
- W2549628327 cites W2062357348 @default.
- W2549628327 cites W2064499831 @default.
- W2549628327 cites W2066558863 @default.
- W2549628327 cites W2066796083 @default.
- W2549628327 cites W2069072174 @default.
- W2549628327 cites W2070385942 @default.
- W2549628327 cites W2072497851 @default.
- W2549628327 cites W2076218507 @default.
- W2549628327 cites W2078115188 @default.
- W2549628327 cites W2078761335 @default.
- W2549628327 cites W2079142824 @default.
- W2549628327 cites W2082046119 @default.
- W2549628327 cites W2082511916 @default.
- W2549628327 cites W2087414776 @default.
- W2549628327 cites W2092916871 @default.
- W2549628327 cites W2094399039 @default.
- W2549628327 cites W2095412415 @default.
- W2549628327 cites W2096081459 @default.
- W2549628327 cites W2099853494 @default.
- W2549628327 cites W2100508256 @default.
- W2549628327 cites W2101873325 @default.
- W2549628327 cites W2102866212 @default.
- W2549628327 cites W2104558356 @default.
- W2549628327 cites W2104692426 @default.
- W2549628327 cites W2119325996 @default.
- W2549628327 cites W2119692843 @default.
- W2549628327 cites W2123647020 @default.
- W2549628327 cites W2130166533 @default.
- W2549628327 cites W2135486162 @default.
- W2549628327 cites W2137634849 @default.
- W2549628327 cites W2139464580 @default.
- W2549628327 cites W2148850534 @default.
- W2549628327 cites W2151957316 @default.
- W2549628327 cites W2158688408 @default.
- W2549628327 cites W2160287592 @default.
- W2549628327 cites W2163326536 @default.
- W2549628327 cites W2166458266 @default.
- W2549628327 cites W2169410023 @default.
- W2549628327 cites W2170726961 @default.
- W2549628327 cites W2171338310 @default.
- W2549628327 cites W2255479470 @default.
- W2549628327 cites W2275318246 @default.
- W2549628327 cites W2298803158 @default.
- W2549628327 cites W2322473773 @default.
- W2549628327 cites W2438292910 @default.
- W2549628327 cites W2466078731 @default.
- W2549628327 cites W247888359 @default.