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• W2549674944 endingPage "989" @default.
• W2549674944 startingPage "981" @default.
• W2549674944 abstract "The tumor suppressor breast cancer 1, early onset (BRCA1) plays an important role in maintaining the genome integrity, actively participating in DNA repair via homologous recombination. The level of functional final BRCA1 protein is precisely regulated in cells. Epigenetic regulation of BRCA1 gene expression is one of the most important mechanisms for BRCA1 level fine-tuning. In this review the main epigenetic mechanisms of BRCA1 expression regulation are presented, including DNA methylation, histone covalent modifications, and regulation with transcription factors. Another important function of BRCA1 emerging in recent years is its role in the regulation of breast cancer stem cell development. Moreover, based on its multiple functions, BRCA1 is also arising as a powerful biomarker. In particular, it could be used as a prognostic marker of the course of the disease and as a predictive marker of the efficiency of platinum-based chemotherapy." @default.
• W2549674944 created "2016-11-30" @default.
• W2549674944 creator A5039031303 @default.
• W2549674944 date "2016-01-01" @default.
• W2549674944 modified "2023-09-26" @default.
• W2549674944 title "Epigenetic regulation of BRCA1 expression and its role inbreast cancer stem cell development" @default.
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• W2549674944 doi "https://doi.org/10.3906/biy-1507-145" @default.
• W2549674944 hasPublicationYear "2016" @default.
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