FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2549748085> ?p ?o ?g. }

• W2549748085 endingPage "e0166682" @default.
• W2549748085 startingPage "e0166682" @default.
• W2549748085 abstract "We hypothesized that L-alpha-glycerylphosphorylcholine (GPC), a deacylatedphosphatidylcholine derivative, can influence the mitochondrial respiratory activity and in this way, may exert tissue protective effects.Rat liver mitochondria were examined with high-resolution respirometry to analyze the effects of GPC on the electron transport chain in normoxic and anoxic conditions. Besides, Sprague-Dawley rats were subjected to sham operation or standardized liver ischemia-reperfusion (IR), with or without GPC administration. The reduced glutathione (GSH) and oxidized glutathione disulfide (GSSG), the tissue myeloperoxidase, xanthine oxidoreductase and NADPH oxidases activities were measured. Tissue malondialdehyde and nitrite/nitrate formation, together with blood superoxide and hydrogen-peroxide production were assessed.GPC increased the efficacy of complex I-linked mitochondrial oxygen consumption, with significantly lower in vitro leak respiration. Mechanistically, liver IR injury was accompanied by deteriorated mitochondrial respiration and enhanced ROS production and, as a consequence, by significantly increased inflammatory enzyme activities. GPC administration decreased the inflammatory activation in line with the reduced oxidative and nitrosative stress markers.GPC, by preserving the mitochondrial complex I function respiration, reduced the biochemical signs of oxidative stress after an IR episode. This suggests that GPC is a mitochondria-targeted compound that indirectly suppresses the activity of major intracellular superoxide-generating enzymes." @default.
• W2549748085 created "2016-11-30" @default.
• W2549748085 creator A5000804327 @default.
• W2549748085 creator A5016258380 @default.
• W2549748085 creator A5040804752 @default.
• W2549748085 creator A5042376096 @default.
• W2549748085 creator A5076484215 @default.
• W2549748085 creator A5079846890 @default.
• W2549748085 date "2016-11-18" @default.
• W2549748085 modified "2023-10-18" @default.
• W2549748085 title "Targeting Mitochondrial Dysfunction with L-Alpha Glycerylphosphorylcholine" @default.
• W2549748085 cites W1481796980 @default.
• W2549748085 cites W1737629705 @default.
• W2549748085 cites W1967499978 @default.
• W2549748085 cites W1987064630 @default.
• W2549748085 cites W1993953434 @default.
• W2549748085 cites W1995326478 @default.
• W2549748085 cites W1995525377 @default.
• W2549748085 cites W2000812004 @default.
• W2549748085 cites W2002411539 @default.
• W2549748085 cites W2006849545 @default.
• W2549748085 cites W2010001303 @default.
• W2549748085 cites W2024407826 @default.
• W2549748085 cites W2025338117 @default.
• W2549748085 cites W2025443964 @default.
• W2549748085 cites W2027022397 @default.
• W2549748085 cites W2027756656 @default.
• W2549748085 cites W2040158221 @default.
• W2549748085 cites W2048668028 @default.
• W2549748085 cites W2053869318 @default.
• W2549748085 cites W2062216067 @default.
• W2549748085 cites W2066207556 @default.
• W2549748085 cites W2071579624 @default.
• W2549748085 cites W2072784856 @default.
• W2549748085 cites W2089090200 @default.
• W2549748085 cites W2090102582 @default.
• W2549748085 cites W2090175505 @default.
• W2549748085 cites W2092569407 @default.
• W2549748085 cites W2101490824 @default.
• W2549748085 cites W2121982881 @default.
• W2549748085 cites W2135289666 @default.
• W2549748085 cites W2136006481 @default.
• W2549748085 cites W2138632104 @default.
• W2549748085 cites W2143151351 @default.
• W2549748085 cites W2143355662 @default.
• W2549748085 cites W2145083175 @default.
• W2549748085 cites W2154123479 @default.
• W2549748085 cites W2156210987 @default.
• W2549748085 cites W2157344997 @default.
• W2549748085 cites W2162937124 @default.
• W2549748085 cites W2229282577 @default.
• W2549748085 cites W2300944587 @default.
• W2549748085 cites W2464236463 @default.
• W2549748085 cites W4235629674 @default.
• W2549748085 cites W4241534679 @default.
• W2549748085 doi "https://doi.org/10.1371/journal.pone.0166682" @default.
• W2549748085 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5115775" @default.
• W2549748085 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27861548" @default.
• W2549748085 hasPublicationYear "2016" @default.
• W2549748085 type Work @default.
• W2549748085 sameAs 2549748085 @default.
• W2549748085 citedByCount "16" @default.
• W2549748085 countsByYear W25497480852017 @default.
• W2549748085 countsByYear W25497480852018 @default.
• W2549748085 countsByYear W25497480852019 @default.
• W2549748085 countsByYear W25497480852020 @default.
• W2549748085 countsByYear W25497480852021 @default.
• W2549748085 countsByYear W25497480852022 @default.
• W2549748085 countsByYear W25497480852023 @default.
• W2549748085 crossrefType "journal-article" @default.
• W2549748085 hasAuthorship W2549748085A5000804327 @default.
• W2549748085 hasAuthorship W2549748085A5016258380 @default.
• W2549748085 hasAuthorship W2549748085A5040804752 @default.
• W2549748085 hasAuthorship W2549748085A5042376096 @default.
• W2549748085 hasAuthorship W2549748085A5076484215 @default.
• W2549748085 hasAuthorship W2549748085A5079846890 @default.
• W2549748085 hasBestOaLocation W25497480851 @default.
• W2549748085 hasConcept C181199279 @default.
• W2549748085 hasConcept C185592680 @default.
• W2549748085 hasConcept C203014093 @default.
• W2549748085 hasConcept C203565725 @default.
• W2549748085 hasConcept C2776151105 @default.
• W2549748085 hasConcept C2776914184 @default.
• W2549748085 hasConcept C2778102346 @default.
• W2549748085 hasConcept C2778175917 @default.
• W2549748085 hasConcept C2778401633 @default.
• W2549748085 hasConcept C2779179908 @default.
• W2549748085 hasConcept C28859421 @default.
• W2549748085 hasConcept C3020377403 @default.
• W2549748085 hasConcept C48349386 @default.
• W2549748085 hasConcept C538909803 @default.
• W2549748085 hasConcept C55493867 @default.
• W2549748085 hasConcept C86803240 @default.
• W2549748085 hasConcept C98274493 @default.
• W2549748085 hasConceptScore W2549748085C181199279 @default.
• W2549748085 hasConceptScore W2549748085C185592680 @default.
• W2549748085 hasConceptScore W2549748085C203014093 @default.
• W2549748085 hasConceptScore W2549748085C203565725 @default.

• next