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• W2549751681 endingPage "86" @default.
• W2549751681 startingPage "1" @default.
• W2549751681 abstract "This review on all spider venom components known by the end of 2010 bases on 1618 records for venom compounds from 174 spider species (= 0.41% of all known species) belonging to 32 families (= 29% of all existing spider families). Spiders investigated for venom research are either big (many mygalomorph species, Nephilidae, Ctenidae and Sparassidae) or medically important for humans (e.g. Loxosceles or Latrodectus species). Venom research widely ignored so far the two most species-rich families (Salticidae and Linyphiidae) and strongly neglected several other very abundant families (Araneidae, Lycosidae, Theridiidae, Thomisidae and Gnaphosidae). We grouped the known 1618 records for venom compounds into six categories: low molecular mass compounds (16 % of all compounds), acylpolyamines (11 %), linear peptides (6 %), cysteine-knotted mini-proteins (60 %), neurotoxic proteins (1 %) and enzymes (6 %). Low molecular mass compounds are known from many spider families and contain organic acids, nucleosides, nucleotides, amino acids, amines, polyamines, and some further substances, many of them acting as neurotransmitters. Acylpolyamines contain amino acids (Araneidae and Nephilidae) or not (several other families) and show a very high diversity within one species. Linear peptides, also called cytolytic, membranolytic or antimicrobial, exert a highly specific structure and are so far only known from Ctenidae, Lycosidae, Oxyopidae and Zodariidae. Cysteine-knotted mini-proteins represent the majority of venom compounds because research so far focused on them. They probably occur in most but not all spider families. Neurotoxic proteins so far are only known from theridiid spiders. Enzymes had been neglected for some time but meanwhile it becomes obvious that they play an important role in spider venoms. Sixteen enzymes either cleave polymers in the extracellular matrix or target phospholipids and related compounds in membranes. The overall structure of these compounds is given and the function, as far as it is known, is described. Since several of these component groups are presented in one average spider venom, we discuss the known interactions and synergisms and give reasons for such a functional redundancy. We also discuss main evolutionary pathways for spider venom compounds such as high variability among components of one group, synergistic interactions between cysteine-knotted mini-proteins and other components (low molecular mass compounds and linear peptides), change of function from ion-channel acting mini-proteins to cytolytic effects and replacement of mini-proteins by linear peptides, acylpolyamines, large proteins or enzymes. We also add first phylogenetic considerations." @default.
• W2549751681 created "2016-11-30" @default.
• W2549751681 creator A5057774538 @default.
• W2549751681 creator A5073493734 @default.
• W2549751681 creator A5083575636 @default.
• W2549751681 date "2011-01-01" @default.
• W2549751681 modified "2023-09-23" @default.
• W2549751681 title "Venom Composition and Strategies in Spiders" @default.
• W2549751681 cites W127587495 @default.
• W2549751681 cites W1438461468 @default.
• W2549751681 cites W1485408222 @default.
• W2549751681 cites W1498797179 @default.
• W2549751681 cites W1501322693 @default.
• W2549751681 cites W1505693447 @default.
• W2549751681 cites W1516030996 @default.
• W2549751681 cites W1516395114 @default.
• W2549751681 cites W1550738149 @default.
• W2549751681 cites W1557004700 @default.
• W2549751681 cites W1584095986 @default.
• W2549751681 cites W1584122033 @default.
• W2549751681 cites W1594106664 @default.
• W2549751681 cites W1773278621 @default.
• W2549751681 cites W1867012516 @default.
• W2549751681 cites W1963568761 @default.
• W2549751681 cites W1963661852 @default.
• W2549751681 cites W1963705468 @default.
• W2549751681 cites W1964774201 @default.
• W2549751681 cites W1965124727 @default.
• W2549751681 cites W1966479384 @default.
• W2549751681 cites W1967283924 @default.
• W2549751681 cites W1967904317 @default.
• W2549751681 cites W1968074835 @default.
• W2549751681 cites W1969028345 @default.
• W2549751681 cites W1969040773 @default.
• W2549751681 cites W1969394759 @default.
• W2549751681 cites W1969986218 @default.
• W2549751681 cites W1970208458 @default.
• W2549751681 cites W1970419100 @default.
• W2549751681 cites W1971428755 @default.
• W2549751681 cites W1971760483 @default.
• W2549751681 cites W1972556534 @default.
• W2549751681 cites W1973756587 @default.
• W2549751681 cites W1974556128 @default.
• W2549751681 cites W1974569205 @default.
• W2549751681 cites W1974653726 @default.
• W2549751681 cites W1975100833 @default.
• W2549751681 cites W1975319165 @default.
• W2549751681 cites W1975419931 @default.
• W2549751681 cites W1975744071 @default.
• W2549751681 cites W1976600378 @default.
• W2549751681 cites W1976718935 @default.
• W2549751681 cites W1976959428 @default.
• W2549751681 cites W1977686336 @default.
• W2549751681 cites W1978217041 @default.
• W2549751681 cites W1978578287 @default.
• W2549751681 cites W1979180704 @default.
• W2549751681 cites W1980203814 @default.
• W2549751681 cites W1980614775 @default.
• W2549751681 cites W1981621681 @default.
• W2549751681 cites W1982028908 @default.
• W2549751681 cites W1982121122 @default.
• W2549751681 cites W1982211525 @default.
• W2549751681 cites W1982282409 @default.
• W2549751681 cites W1982881459 @default.
• W2549751681 cites W1983333628 @default.
• W2549751681 cites W1983811485 @default.
• W2549751681 cites W1983876877 @default.
• W2549751681 cites W1984302148 @default.
• W2549751681 cites W1984752727 @default.
• W2549751681 cites W1985128045 @default.
• W2549751681 cites W1985899388 @default.
• W2549751681 cites W1987460091 @default.
• W2549751681 cites W1988349777 @default.
• W2549751681 cites W1989237379 @default.
• W2549751681 cites W1989998611 @default.
• W2549751681 cites W1991412472 @default.
• W2549751681 cites W1992126189 @default.
• W2549751681 cites W1992532108 @default.
• W2549751681 cites W1992731370 @default.
• W2549751681 cites W1993395883 @default.
• W2549751681 cites W1997358556 @default.
• W2549751681 cites W1998104052 @default.
• W2549751681 cites W1998469753 @default.
• W2549751681 cites W1998616287 @default.
• W2549751681 cites W1999058895 @default.
• W2549751681 cites W2000630492 @default.
• W2549751681 cites W2001501807 @default.
• W2549751681 cites W2005782719 @default.
• W2549751681 cites W2006733323 @default.
• W2549751681 cites W2006834442 @default.
• W2549751681 cites W2006926361 @default.
• W2549751681 cites W2009106357 @default.
• W2549751681 cites W2009152806 @default.
• W2549751681 cites W2009190740 @default.
• W2549751681 cites W2009440109 @default.
• W2549751681 cites W2009872645 @default.
• W2549751681 cites W2009985769 @default.
• W2549751681 cites W2010632030 @default.

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