Matches in SemOpenAlex for { <https://semopenalex.org/work/W2549763709> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W2549763709 abstract "Serotonin (5-HT) neurons in both medullary and midbrain raphe nuclei sense changes in the partial pressure of arterial CO 2 . Arousal from sleep in response to hypercapnia (i.e., CO 2 -induced arousal) may be important in diseases such as obstructive sleep apnea syndrome (OSA) and sudden infant death syndrome (SIDS). 5-HT neurons are reportedly necessary for CO 2 -induced arousal, although the underlying mechanism is not understood. Here, we examined how central 5-HT neurons contribute to sleep/wake regulation during hypercapnia by using optogenetic methods to selectively stimulate or suppress specific serotonergic neuronal populations. We used transgenic mice (provided by the RIKEN Bio Resource Center) in which central 5-HT neurons were genetically targeted by archaerhodopsin, a green light-driven neuronal silencer, or by channelrhodopsin-2, a blue light-driven neuronal activator. An optical fiber (diameter, 0.5 mm) was inserted just above the dorsal raphe (DR) or the raphe obscurus (RO), and an EEG/EMG telemeter was implanted subcutaneously in each mouse. After 10 days of recovery, the mice were placed in a whole-body plethysmograph (EMKA Technologies), and the optical fibers were illuminated by a telemetric system (Teleopto, Bio Research Center) during CO 2 inhalation. All vigilance state classifications assigned by analyzing software (Sleep Sign, KISSEI COMTEC) were confirmed visually and corrected if necessary. The present study tested our hypothesis that DR and RO 5-HT neurons play a crucial role in CO 2 -induced arousal. Further investigation of the underlying serotonergic mechanisms may lead to development of pharmacotherapies that reduce morbidity and mortality from SIDS and OSA." @default.
- W2549763709 created "2016-11-30" @default.
- W2549763709 creator A5013990536 @default.
- W2549763709 creator A5015298849 @default.
- W2549763709 creator A5021224935 @default.
- W2549763709 creator A5057153260 @default.
- W2549763709 creator A5059378498 @default.
- W2549763709 creator A5063339845 @default.
- W2549763709 creator A5078982142 @default.
- W2549763709 creator A5080787179 @default.
- W2549763709 date "2016-09-01" @default.
- W2549763709 modified "2023-09-27" @default.
- W2549763709 title "Optogenetic silencing of selected serotonin neurons in the control of CO2-induced arousal" @default.
- W2549763709 doi "https://doi.org/10.1183/13993003.congress-2016.pa2299" @default.
- W2549763709 hasPublicationYear "2016" @default.
- W2549763709 type Work @default.
- W2549763709 sameAs 2549763709 @default.
- W2549763709 citedByCount "0" @default.
- W2549763709 crossrefType "proceedings-article" @default.
- W2549763709 hasAuthorship W2549763709A5013990536 @default.
- W2549763709 hasAuthorship W2549763709A5015298849 @default.
- W2549763709 hasAuthorship W2549763709A5021224935 @default.
- W2549763709 hasAuthorship W2549763709A5057153260 @default.
- W2549763709 hasAuthorship W2549763709A5059378498 @default.
- W2549763709 hasAuthorship W2549763709A5063339845 @default.
- W2549763709 hasAuthorship W2549763709A5078982142 @default.
- W2549763709 hasAuthorship W2549763709A5080787179 @default.
- W2549763709 hasConcept C126322002 @default.
- W2549763709 hasConcept C169760540 @default.
- W2549763709 hasConcept C170493617 @default.
- W2549763709 hasConcept C2775864247 @default.
- W2549763709 hasConcept C2777615928 @default.
- W2549763709 hasConcept C2777865548 @default.
- W2549763709 hasConcept C2778468602 @default.
- W2549763709 hasConcept C2779320081 @default.
- W2549763709 hasConcept C32610206 @default.
- W2549763709 hasConcept C36951298 @default.
- W2549763709 hasConcept C37000724 @default.
- W2549763709 hasConcept C50738837 @default.
- W2549763709 hasConcept C522805319 @default.
- W2549763709 hasConcept C529278444 @default.
- W2549763709 hasConcept C71924100 @default.
- W2549763709 hasConcept C86803240 @default.
- W2549763709 hasConceptScore W2549763709C126322002 @default.
- W2549763709 hasConceptScore W2549763709C169760540 @default.
- W2549763709 hasConceptScore W2549763709C170493617 @default.
- W2549763709 hasConceptScore W2549763709C2775864247 @default.
- W2549763709 hasConceptScore W2549763709C2777615928 @default.
- W2549763709 hasConceptScore W2549763709C2777865548 @default.
- W2549763709 hasConceptScore W2549763709C2778468602 @default.
- W2549763709 hasConceptScore W2549763709C2779320081 @default.
- W2549763709 hasConceptScore W2549763709C32610206 @default.
- W2549763709 hasConceptScore W2549763709C36951298 @default.
- W2549763709 hasConceptScore W2549763709C37000724 @default.
- W2549763709 hasConceptScore W2549763709C50738837 @default.
- W2549763709 hasConceptScore W2549763709C522805319 @default.
- W2549763709 hasConceptScore W2549763709C529278444 @default.
- W2549763709 hasConceptScore W2549763709C71924100 @default.
- W2549763709 hasConceptScore W2549763709C86803240 @default.
- W2549763709 hasLocation W25497637091 @default.
- W2549763709 hasOpenAccess W2549763709 @default.
- W2549763709 hasPrimaryLocation W25497637091 @default.
- W2549763709 hasRelatedWork W1658437126 @default.
- W2549763709 hasRelatedWork W1898186924 @default.
- W2549763709 hasRelatedWork W1968988215 @default.
- W2549763709 hasRelatedWork W1997335213 @default.
- W2549763709 hasRelatedWork W2037463836 @default.
- W2549763709 hasRelatedWork W2114733595 @default.
- W2549763709 hasRelatedWork W2152193409 @default.
- W2549763709 hasRelatedWork W2301439114 @default.
- W2549763709 hasRelatedWork W2320456615 @default.
- W2549763709 hasRelatedWork W2399181424 @default.
- W2549763709 hasRelatedWork W2440336360 @default.
- W2549763709 hasRelatedWork W2553094875 @default.
- W2549763709 hasRelatedWork W2776533731 @default.
- W2549763709 hasRelatedWork W2792390588 @default.
- W2549763709 hasRelatedWork W2799284787 @default.
- W2549763709 hasRelatedWork W2889026404 @default.
- W2549763709 hasRelatedWork W2913431982 @default.
- W2549763709 hasRelatedWork W3129135988 @default.
- W2549763709 hasRelatedWork W3160264665 @default.
- W2549763709 hasRelatedWork W2182563492 @default.
- W2549763709 isParatext "false" @default.
- W2549763709 isRetracted "false" @default.
- W2549763709 magId "2549763709" @default.
- W2549763709 workType "article" @default.