Matches in SemOpenAlex for { <https://semopenalex.org/work/W254989727> ?p ?o ?g. }
- W254989727 abstract "Abstract : Meniscal injuries are the most common traumatic leg injuries, accounting for over half of the knee arthroscopies performed each year. Damaged menisci rarely regain normal structural integrity or mechanical strength, and surgical repair cannot reliably prevent the degenerative changes that occur post injury and presage the development of knee osteoarthritis (OA). New treatments centered on the stem/progenitor cell population resident within the adult meniscus will be key to derailing the connection between acute meniscal injury and post-traumatic knee OA. Here we combine mouse genetics with molecular and cell biology to develop a profile of repair cells in the adult meniscus, track meniscal stem/progenitor cell (MSPC) behavior within meniscus as function of age, and assess the contribution of resident MSPCs to repair after meniscal injury. During the current research period: we made significant progress toward our goals by establishing a standard protocol for harvesting MSPCs from 8 week, 6 month and 1-year old mouse menisci. MSPCs grow as colonies, express stem cell and meniscal gene signature markers found in adult human meniscus, and can be successfully passaged. We also piloted a novel mouse meniscal tear injury model, and are now ready to use this technique for experiments outlined in our proposal." @default.
- W254989727 created "2016-06-24" @default.
- W254989727 creator A5057133148 @default.
- W254989727 date "2014-09-01" @default.
- W254989727 modified "2023-09-24" @default.
- W254989727 title "Identification, Characterization, and Utilization of Adult Meniscal Progenitor Cells" @default.
- W254989727 cites W1511673676 @default.
- W254989727 cites W1542654261 @default.
- W254989727 cites W1580307320 @default.
- W254989727 cites W1807713007 @default.
- W254989727 cites W1871971828 @default.
- W254989727 cites W1878764117 @default.
- W254989727 cites W1970102846 @default.
- W254989727 cites W1972107750 @default.
- W254989727 cites W1977026225 @default.
- W254989727 cites W1980359589 @default.
- W254989727 cites W1982628350 @default.
- W254989727 cites W1984357997 @default.
- W254989727 cites W1988005968 @default.
- W254989727 cites W1988188434 @default.
- W254989727 cites W1989837808 @default.
- W254989727 cites W1998526146 @default.
- W254989727 cites W1999766372 @default.
- W254989727 cites W2002251686 @default.
- W254989727 cites W2002999171 @default.
- W254989727 cites W2003328208 @default.
- W254989727 cites W2005321018 @default.
- W254989727 cites W2006219097 @default.
- W254989727 cites W2010184087 @default.
- W254989727 cites W2021306415 @default.
- W254989727 cites W2022097969 @default.
- W254989727 cites W2022805915 @default.
- W254989727 cites W2025387481 @default.
- W254989727 cites W2030453203 @default.
- W254989727 cites W2031144025 @default.
- W254989727 cites W2034084493 @default.
- W254989727 cites W2035073055 @default.
- W254989727 cites W2038975231 @default.
- W254989727 cites W2041334904 @default.
- W254989727 cites W2043892505 @default.
- W254989727 cites W2050606344 @default.
- W254989727 cites W2052009573 @default.
- W254989727 cites W2054221638 @default.
- W254989727 cites W2055142018 @default.
- W254989727 cites W2055617421 @default.
- W254989727 cites W2056959599 @default.
- W254989727 cites W2065998075 @default.
- W254989727 cites W2067545768 @default.
- W254989727 cites W2072929517 @default.
- W254989727 cites W2074916651 @default.
- W254989727 cites W2087669457 @default.
- W254989727 cites W2105254650 @default.
- W254989727 cites W2107277218 @default.
- W254989727 cites W2109415576 @default.
- W254989727 cites W2116603780 @default.
- W254989727 cites W2118963985 @default.
- W254989727 cites W2126820503 @default.
- W254989727 cites W2130806884 @default.
- W254989727 cites W2135616992 @default.
- W254989727 cites W2137504924 @default.
- W254989727 cites W2140405544 @default.
- W254989727 cites W2142261518 @default.
- W254989727 cites W2152327681 @default.
- W254989727 cites W2158837806 @default.
- W254989727 cites W2160991148 @default.
- W254989727 cites W2166289282 @default.
- W254989727 cites W2168702740 @default.
- W254989727 cites W2171126701 @default.
- W254989727 cites W2318943386 @default.
- W254989727 cites W2441009440 @default.
- W254989727 doi "https://doi.org/10.21236/ada613480" @default.
- W254989727 hasPublicationYear "2014" @default.
- W254989727 type Work @default.
- W254989727 sameAs 254989727 @default.
- W254989727 citedByCount "0" @default.
- W254989727 crossrefType "report" @default.
- W254989727 hasAuthorship W254989727A5057133148 @default.
- W254989727 hasConcept C120665830 @default.
- W254989727 hasConcept C121332964 @default.
- W254989727 hasConcept C141071460 @default.
- W254989727 hasConcept C142724271 @default.
- W254989727 hasConcept C189178095 @default.
- W254989727 hasConcept C201750760 @default.
- W254989727 hasConcept C204787440 @default.
- W254989727 hasConcept C2776164576 @default.
- W254989727 hasConcept C28328180 @default.
- W254989727 hasConcept C2908647359 @default.
- W254989727 hasConcept C61511704 @default.
- W254989727 hasConcept C71924100 @default.
- W254989727 hasConcept C86803240 @default.
- W254989727 hasConcept C95444343 @default.
- W254989727 hasConcept C99454951 @default.
- W254989727 hasConceptScore W254989727C120665830 @default.
- W254989727 hasConceptScore W254989727C121332964 @default.
- W254989727 hasConceptScore W254989727C141071460 @default.
- W254989727 hasConceptScore W254989727C142724271 @default.
- W254989727 hasConceptScore W254989727C189178095 @default.
- W254989727 hasConceptScore W254989727C201750760 @default.
- W254989727 hasConceptScore W254989727C204787440 @default.
- W254989727 hasConceptScore W254989727C2776164576 @default.